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May 29

TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks

Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope binding specificity. Scarcity of data and a large sequence space make this task challenging, and to date only models limited to a small set of epitopes have achieved good performance. Here, we establish a k-nearest-neighbor (K-NN) classifier as a strong baseline and then propose TITAN (Tcr epITope bimodal Attention Networks), a bimodal neural network that explicitly encodes both TCR sequences and epitopes to enable the independent study of generalization capabilities to unseen TCRs and/or epitopes. Results: By encoding epitopes at the atomic level with SMILES sequences, we leverage transfer learning and data augmentation to enrich the input data space and boost performance. TITAN achieves high performance in the prediction of specificity of unseen TCRs (ROC-AUC 0.87 in 10-fold CV) and surpasses the results of the current state-of-the-art (ImRex) by a large margin. Notably, our Levenshtein-distance-based K-NN classifier also exhibits competitive performance on unseen TCRs. While the generalization to unseen epitopes remains challenging, we report two major breakthroughs. First, by dissecting the attention heatmaps, we demonstrate that the sparsity of available epitope data favors an implicit treatment of epitopes as classes. This may be a general problem that limits unseen epitope performance for sufficiently complex models. Second, we show that TITAN nevertheless exhibits significantly improved performance on unseen epitopes and is capable of focusing attention on chemically meaningful molecular structures.

  • 3 authors
·
Apr 21, 2021

Exploring Light-Weight Object Recognition for Real-Time Document Detection

Object Recognition and Document Skew Estimation have come a long way in terms of performance and efficiency. New models follow one of two directions: improving performance using larger models, and improving efficiency using smaller models. However, real-time document detection and rectification is a niche that is largely unexplored by the literature, yet it remains a vital step for automatic information retrieval from visual documents. In this work, we strive towards an efficient document detection pipeline that is satisfactory in terms of Optical Character Recognition (OCR) retrieval and faster than other available solutions. We adapt IWPOD-Net, a license plate detection network, and train it for detection on NBID, a synthetic ID card dataset. We experiment with data augmentation and cross-dataset validation with MIDV (another synthetic ID and passport document dataset) to find the optimal scenario for the model. Other methods from both the Object Recognition and Skew Estimation state-of-the-art are evaluated for comparison with our approach. We use each method to detect and rectify the document, which is then read by an OCR system. The OCR output is then evaluated using a novel OCR quality metric based on the Levenshtein distance. Since the end goal is to improve automatic information retrieval, we use the overall OCR quality as a performance metric. We observe that with a promising model, document rectification does not have to be perfect to attain state-of-the-art performance scores. We show that our model is smaller and more efficient than current state-of-the-art solutions while retaining a competitive OCR quality metric. All code is available at https://github.com/BOVIFOCR/iwpod-doc-corners.git

  • 4 authors
·
Sep 7, 2025

Generating Narrated Lecture Videos from Slides with Synchronized Highlights

Turning static slides into engaging video lectures takes considerable time and effort, requiring presenters to record explanations and visually guide their audience through the material. We introduce an end-to-end system designed to automate this process entirely. Given a slide deck, this system synthesizes a video lecture featuring AI-generated narration synchronized precisely with dynamic visual highlights. These highlights automatically draw attention to the specific concept being discussed, much like an effective presenter would. The core technical contribution is a novel highlight alignment module. This module accurately maps spoken phrases to locations on a given slide using diverse strategies (e.g., Levenshtein distance, LLM-based semantic analysis) at selectable granularities (line or word level) and utilizes timestamp-providing Text-to-Speech (TTS) for timing synchronization. We demonstrate the system's effectiveness through a technical evaluation using a manually annotated slide dataset with 1000 samples, finding that LLM-based alignment achieves high location accuracy (F1 > 92%), significantly outperforming simpler methods, especially on complex, math-heavy content. Furthermore, the calculated generation cost averages under $1 per hour of video, offering potential savings of two orders of magnitude compared to conservative estimates of manual production costs. This combination of high accuracy and extremely low cost positions this approach as a practical and scalable tool for transforming static slides into effective, visually-guided video lectures.

  • 1 authors
·
May 5, 2025