prompt stringlengths 2.15k 5.36k | title stringclasses 394
values | abstract stringclasses 394
values | head_entity dict | title_entity dict | candidate_relation_list sequencelengths 3 7 | label stringclasses 8
values |
|---|---|---|---|---|---|---|
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Hepatocyte nuclear factor-6 and a disease type II diabetes in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The me... | Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. | The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus... | {
"name": "Hepatocyte nuclear factor-6",
"type": "GeneOrGeneProduct"
} | {
"name": "type II diabetes",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical glucose and a gene or protein insulin in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each relat... | Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. | The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus... | {
"name": "glucose",
"type": "ChemicalEntity"
} | {
"name": "insulin",
"type": "GeneOrGeneProduct"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical glucose and a disease Type II diabetes mellitus in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each re... | Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. | The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus... | {
"name": "glucose",
"type": "ChemicalEntity"
} | {
"name": "Type II diabetes mellitus",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein type II Ca2+-dependent lectin and a chemical mannose in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The m... | Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. | We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin. LC are uniquely characterized by Birbeck granules (BG), which are organelles consisting of superimposed and zippered membranes. Here, we have shown that Langerin... | {
"name": "type II Ca2+-dependent lectin",
"type": "GeneOrGeneProduct"
} | {
"name": "mannose",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Bind |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease breast cancer and a variant 5382insC in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "breast cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "5382insC",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease breast cancer and a variant 4153delA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "breast cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "4153delA",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease breast cancer and a variant C61G in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "breast cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "C61G",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease ovarian cancer and a variant 5382insC in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "5382insC",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease ovarian cancer and a variant 4153delA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "4153delA",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease ovarian cancer and a variant C61G in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "C61G",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant 5382insC and a disease breast-ovarian cancer syndrome in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of ea... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "5382insC",
"type": "SequenceVariant"
} | {
"name": "breast-ovarian cancer syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant 4153delA and a disease breast-ovarian cancer syndrome in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of ea... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "4153delA",
"type": "SequenceVariant"
} | {
"name": "breast-ovarian cancer syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant C61G and a disease breast-ovarian cancer syndrome in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each r... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "C61G",
"type": "SequenceVariant"
} | {
"name": "breast-ovarian cancer syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease BRCA1 abnormalities and a variant 5382insC in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "5382insC",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease BRCA1 abnormalities and a variant 4153delA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "4153delA",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease BRCA1 abnormalities and a variant C61G in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation typ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "C61G",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease breast cancers in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "breast cancers",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease ovarian cancer in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease BRCA1 abnormalities in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rel... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease breast-ovarian cancer in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each r... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "breast-ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical levodopa and a disease dyskinesias in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type a... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "levodopa",
"type": "ChemicalEntity"
} | {
"name": "dyskinesias",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical apomorphine and a chemical levodopa in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'], based only on the informa... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "apomorphine",
"type": "ChemicalEntity"
} | {
"name": "levodopa",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Drug_Interaction",
"Cotreatment",
"Conversion",
"Comparison",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical apomorphine and a disease dyskinesias in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation typ... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "apomorphine",
"type": "ChemicalEntity"
} | {
"name": "dyskinesias",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical Apomorphine and a disease Parkinson's disease in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rela... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "Apomorphine",
"type": "ChemicalEntity"
} | {
"name": "Parkinson's disease",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease uterine sarcoma and a gene or protein Rab6c in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relatio... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "uterine sarcoma",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical vincristine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each rel... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "vincristine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical vinblastine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each rel... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "vinblastine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical taxol in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each relation ... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "taxol",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical doxorubicin in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each rel... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "doxorubicin",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein calcineurin and a chemical tacrolimus in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of eac... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "calcineurin",
"type": "GeneOrGeneProduct"
} | {
"name": "tacrolimus",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein calcineurin and a chemical cyclosporine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of e... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "calcineurin",
"type": "GeneOrGeneProduct"
} | {
"name": "cyclosporine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease hepatorenal syndrome and a chemical creatinine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rela... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "hepatorenal syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "creatinine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical tacrolimus and a disease nephrotoxic in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "tacrolimus",
"type": "ChemicalEntity"
} | {
"name": "nephrotoxic",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease CRF and a chemical creatinine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are as ... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "CRF",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "creatinine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical cyclosporine and a disease nephrotoxic in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation ty... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "cyclosporine",
"type": "ChemicalEntity"
} | {
"name": "nephrotoxic",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
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