text stringlengths 1.07k 93k | summary stringlengths 40 5.44k | subset stringclasses 16
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package tfe
import (
"bytes"
"context"
"encoding/json"
"errors"
"fmt"
"io"
"math/rand"
"net/http"
"net/url"
"os"
"reflect"
"strconv"
"strings"
"time"
"github.com/google/go-querystring/query"
"github.com/hashicorp/go-cleanhttp"
retryablehttp "github.com/hashicorp/go-retryablehttp"
"github.com/svanhar... | The code is a Go package that allows users to access the Terraform Enterprise API. It includes functions for making API requests, handling authentication, and parsing responses. The code also defines constants and error types. External libraries are used for handling HTTP requests and JSON parsing. | stacksmol |
Protein function is encoded within protein sequence and protein domains. However, how protein domains cooperate within a protein to modulate overall activity and how this impacts functional diversification at the molecular and organism levels remains largely unaddressed. Focusing on three domains of the central class D... | Proteins perform essential regulatory functions, including control of gene transcription, a process central to development, evolution, and disease. While protein domains important for protein activity have been identified, how they act together to define the activity of a protein remains poorly explored. The predominan... | lay_plos |
Genome-scale metabolic models are available for an increasing number of organisms and can be used to define the region of feasible metabolic flux distributions. In this work we use as constraints a small set of experimental metabolic fluxes, which reduces the region of feasible metabolic states. Once the region of feas... | The sequencing of full genomes and the development of high-throughput analysis technologies have made available both genome-scale metabolic networks and simultaneous transcription data for all the genes of an organism. Genome-scale metabolic models, with the assumption of steady state for the internal metabolites, allo... | lay_plos |
At least 25 inherited disorders in humans result from microsatellite repeat expansion. Dramatic variation in repeat instability occurs at different disease loci and between different tissues; however, cis-elements and trans-factors regulating the instability process remain undefined. Genomic fragments from the human sp... | The human genome contains many repetitive sequences. In 1991, we discovered that excessive lengthening of a three-nucleotide (trinucleotide) repeat sequence could cause a human genetic disease. We now know that this unique type of genetic mutation, known as a "repeat expansion," occurs in at least 25 different diseases... | lay_plos |
Background Interoperable communications is not an end in itself. Rather, it is a necessary means for achieving an important goal—the ability to respond effectively to and mitigate incidents that require the coordinated actions of first responders, such as multi-vehicle accidents, natural disasters, or terrorist attacks... | Lives of first responders and those whom they are trying to assist can be lost when first responders cannot communicate effectively as needed. This report addresses issues of determining the status of interoperable wireless communications across the nation, and the potential roles that federal state, local governments ... | gov_report |
RELATED APPLICATIONS [0001] This application claims the benefit of Japanese Application No. JP2002-361900, filed Dec. 13, 2002, which is incorporated by reference herein in its entirety. TECHNICAL FIELD OF THE INVENTION [0002] The present invention relates to a film forming agent for coating plants and a method for sup... | The present invention provides compositions and methods of use and application of such compositions that not only ensure that necessary nutrients are supplied to plants but also harmlessly and reliably prevent damage to plants caused by harmful insects. The compositions include film forming agents for coating plants th... | big_patent |
[Scene: The Bay Mirror. Phoebe walks in and goes over to her assistant.]
Phoebe: Good morning. Any phone calls?
Assistant: Take your pick. We've got adulterers, cross-dressers, thirty-four year old virgins, and, oh, your nephew.
Phoebe: Oh, Chris called?
Assistant: No, Wyatt. Um, actually, I think Piper did the diallin... | Phoebe frees a genie, Jinny ( Saba Homayoon ), from a bottle, only to find that Jinny is a demon that has tricked her into becoming a genie herself. Anxious to get Leo and Piper back together so he can be conceived, Chris uses Phoebe to make his wish come true, but she takes his instructions too literally. When Chris r... | summ_screen_fd |
Identification of functional genetic variation associated with increased susceptibility to complex diseases can elucidate genes and underlying biochemical mechanisms linked to disease onset and progression. For genes linked to genetic diseases, most identified causal mutations alter an encoded protein sequence. Technol... | DNA sequence variations (polymorphisms) that affect the expression levels of genes play important roles in the pathogenesis of many complex diseases. Compared with genetic variations that alter the amino acid sequences of encoded proteins, which are relatively easy to identify, sequence variants that affect the regulat... | lay_plos |
Regulation of rod gene expression has emerged as a potential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP). We previously reported on a small molecule modulator of the rod transcription factor Nr2e3, Photoregulin1 (PR1), that regulates the expression of photoreceptor-specifi... | There are several diseases that cause people to lose their eyesight and become blind. One of these diseases, called retinitis pigmentosa, kills cells at the back of the eye known as rod cells. At first, it affects vision in low light and peripheral vision, but later it affects vision during the daytime as well. There a... | lay_elife |
Neurocysticercosis is a disease caused by the oral ingestion of eggs from the human parasitic worm Taenia solium. Although drugs are available they are controversial because of the side effects and poor efficiency. An expressed sequence tag (EST) library is a method used to describe the gene expression profile and sequ... | A method used to describe expressed genes at a specific stage in an organism is an EST library. In this method mRNA from a specific organism is isolated, transcribed into cDNA and sequenced. The sequence will derive from the 5′-end of the cDNA. The library will not have sequences from all genes, especially if they are ... | lay_plos |
The 2014/2015 West African Ebola Virus Disease (EVD) outbreak attracted global attention. Numerous opinions claimed that the global response was impaired, in part because, the EVD research was neglected, although quantitative or qualitative studies did not exist. Our objective was to analyse how the EVD research landsc... | Ebola Virus Disease (EVD) research publications were used to analyse and visualise collaborations between institutions jointly publishing research results, using freely available social network analysis tools. Constructed co-authorship networks between author affiliated institutions showed EVD research publications inc... | lay_plos |
Hepatitis C virus (HCV) entry, translation, replication, and assembly occur with defined kinetics in distinct subcellular compartments. It is unclear how HCV spatially and temporally regulates these events within the host cell to coordinate its infection. We have developed a single molecule RNA detection assay that fac... | The stages of the viral life cycle are spatially and temporally regulated to coordinate the infectious process in a way that maximizes successful replication and spread. In this study, we used RNA in situ hybridization (ISH) to simultaneously detect HCV (+) and (−) RNAs and analyze the kinetics of HCV infection at the ... | lay_plos |
Introduction Congress has many techniques for obtaining documents from the executive branch, including simple requests, committee investigations, subpoenas, and holding executive officials in contempt. One procedure, used only in the House of Representatives, is the resolution of inquiry, which "is a simple resolution ... | The resolution of inquiry is a simple House resolution that seeks factual information from the executive branch. Such resolutions are given privileged status under House rules and may be considered at any time after being properly reported or discharged from committee. Such resolutions apply only to requests for facts-... | gov_report |
At least three young Minnesota women are now believed to have traveled to Syria to give aid to the ISIS terror group responsible for the brutal beheadings of American journalists, MailOnline has learned. The trio left some three weeks ago, Omar Jamal, a leader of the Somali community in the state capital, St. Paul, tel... | Three girls left Minnesota three weeks ago to join ISIS insurgents in Syria. Their identities have not yet been revealed. The FBI has subpoenaed a 19-year-old girl's family to appear before a Grand Jury later this month. She was about to start nursing classes at St. Paul College but decided to leave to give aid to woun... | cnn_dailymail |
Vision is the dominant sensory modality in many organisms for foraging, predator avoidance, and social behaviors including mate selection. Vertebrate visual perception is initiated when light strikes rod and cone photoreceptors within the neural retina of the eye. Sensitivity to individual colors, i. e., peak spectral ... | Vertebrate color vision is possible when cone visual pigments with distinct peak spectral sensitivities (λmax) are expressed in separate cone populations and provide differential input to downstream neurons. The λmax is a function of the type of chromophore (such as 11-cis retinal) and the amino acid sequence of the as... | lay_plos |
As a fresh batch of leaked files gave new urgency to worldwide controversy surrounding the publication of US diplomatic communiqués, there was continued mystery over the motivation, intentions and whereabouts of the man at the heart of the whistle-blowing website Wikileaks. Despite accusations that Julian Assange is on... | With Interpol seeking to bring him into custody on rape charges and people including Sarah Palin and Bill O'Reilly calling for his head, it may be a while before Julian Assange turns up at a press conference-but the Independent claims to know where he is. It reports that the WikiLeaks founder provided Britain's Metropo... | multi_news |
The possibility that a new black independent film movement — or even a genuinely crossover cinema — would emerge in the wake of “Precious: Based on the Novel ‘Push’ by Sapphire,” now seems as remote as it did before this art-house phenomenon made its way, assisted by Oprah Winfrey and Tyler Perry, from the Sundance Fil... | Whoopi Goldberg has lashed out at the New York Times for an article on how no black actors are being considered for Academy Awards this year. While Goldberg can sympathize with the article's main thrust, it's the fact that the authors-movie critics AO Scott and Manohla Dargis-seem to list every black Academy Award winn... | multi_news |
Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence. Although it has been suggested that the electroneutral Na+-K+-Cl− cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism by which this ion transporter contributes to GB aggressiveness remains ... | Treatment of many cancers has been hampered by the invasive ability of tumor cells. A notable example is brain cancer, which is incurable due to its invasiveness and resulting high tumor recurrence after surgical resection. Here, we analyze further the function of NKCC1, an ion transporter that is known to regulate cel... | lay_plos |
DNA polymerase ν (pol ν), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth analysis of pol ν–defective mice and human cells. POLN is very weakly expressed in most tissues, with the highest relative expression in testis. We constructed mult... | The work described here fills a current gap in the study of the 16 known DNA polymerases in vertebrate genomes. Until now, experiments with genetically disrupted mice have been reported for all but pol ν, encoded by the POLN gene. To intensively analyze the role of mammalian pol ν we generated multiple Poln-deficient m... | lay_plos |
Background PTSD can develop following exposure to combat, natural disasters, terrorist incidents, serious accidents, or violent personal assaults like rape. People who experience stressful events often relive the experience through nightmares and flashbacks, have difficulty sleeping, and feel detached or estranged. The... | Many servicemembers supporting Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) have engaged in intense and prolonged combat, which research has shown to be strongly associated with the risk of developing post-traumatic stress disorder (PTSD). GAO, in response to the Ronald W. Reagan National Defense ... | gov_report |
Active sensing organisms, such as bats, dolphins, and weakly electric fish, generate a 3-D space for active sensation by emitting self-generated energy into the environment. For a weakly electric fish, we demonstrate that the electrosensory space for prey detection has an unusual, omnidirectional shape. We compare this... | Most animals, including humans, have sensory and motor capabilities that are biased in the forward direction. The black ghost knifefish, a nocturnal, weakly electric fish from the Amazon, is an interesting exception to this general rule. We demonstrate that these fish have sensing and motor capabilities that are omnidi... | lay_plos |
By Ceri JacksonBBC News When the young Aristotle Onassis would sail in Cardiff's Tiger Bay, he always headed for one place. Away from the high commerce and architectural splendour of the dockland's banking halls and buildings - a stately procession of Georgian, Victorian and Edwardian-style magnificence befitting the w... | On Monday #towerlives kicks off, a week-long BBC festival of storytelling and music, on air and on the ground, in and around the council estate tower blocks of Butetown in Cardiff. Its aim is to give a platform to voices from a community often talked about but rarely heard. In the first of a series of stories from the ... | xlsum_en |
FIELD OF THE INVENTION [0001] The present invention relates to intravascular neutron capture therapy. More particularly, the present invention provides methods and apparatus for making and using an implantable stent comprising a material capable of reducing restenosis, thereby improving long-term patency of the implant... | Improved method and apparatus for neutron capture therapy are disclosed, which may beneficially be used to counteract restenosis. An improved stent and a method for manufacturing the stent are also presented. The stent comprises a stable nuclide having a large neutron capture cross-section. When a clinical need exists ... | big_patent |
Alexander Litvinenko’s accusation that Vladimir Putin was a paedophile may have been one of the motives for the Russian government to order his assassination, a report into the former Russian spy's death has found. Sir Robert Owen’s inquiry looked at the former FSB agent’s “highly personal attacks” on the Russian Presi... | A British judge declared a remarkable thing Thursday: Vladimir Putin is "probably" a murderer. The finding came after an inquiry into the high-profile death of former KGB officer Alexander Litvinenko, who was fatally poisoned in 2006. Judge Robert Owen said he's certain that two Russian agents laced Litvinenko's green ... | multi_news |
The large conductance, voltage- and calcium-dependent potassium (BK) channel serves as a major negative feedback regulator of calcium-mediated physiological processes and has been implicated in muscle dysfunction and neurological disorders. In addition to membrane depolarization, activation of the BK channel requires a... | Calcium ions are essential for many physiological processes, including neurosecretion and neuronal and muscle excitation. Paradoxically, abnormal accumulation of calcium ions is associated with cell death and has been documented as an early event in muscle and neural degenerative diseases. One mechanism to avoid detrim... | lay_plos |
Insects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threatens the sustainability of malaria vector control programs in sub-Saha... | Malaria, a disease spread by anopheline mosquitoes, is a global health problem with an enormous economic and social impact. Pyrethroid insecticides are critical in reducing malaria transmission, and resistance to these insecticides threatens current control efforts. With a limited number of public health insecticides a... | lay_plos |
Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to rationally develop an HIV-1 vaccine. We previously identified a participant in the CAPRISA Acute Infection Cohort (CAP257) whose plasma neutralized 84% of heterologou... | Four sites of vulnerability for broadly neutralizing antibodies to HIV-1 have been identified thus far. How these broadly reactive antibodies arise, and the host-pathogen interactions that drive the affinity maturation necessary for neutralization breadth are poorly understood. This study details the sequential develop... | lay_plos |
[PREVIOUSLY_ON]
Fred: "Handsome man. Saved me from the monsters."
Gunn: "Anyone talked Fred lately?"
Angel: "She's been back in this world for three months and she still hasn't gone out into it."
Gavin: "I'm working on a little something aimed at Angel Investigations."
Lilah: "What are you doing? Building code violatio... | While investigating some mysterious deaths, Angel switches bodies with a old guy named Marcus. Marcus immediately takes over Angel's life, while Angel is stuck in a retirement home. When Marcus realizes that Angel's body gives him vampire powers, he decides that they only way to keep it is to get rid of Angel once and ... | summ_screen_fd |
UIW police officer involved in fatal shooting SAN ANTONIO — Just before University of the Incarnate Word senior Robert Cameron Redus was fatally shot in a struggle with a UIW police officer Friday morning, a neighbor overheard what may have been his last words. “I heard (a man) say, 'Oh, you're gonna shoot me?'” in a s... | A student at a Christian university was shot dead on Friday for allegedly resisting arrest, but fellow students are struggling to believe the official story, CNN reports. It goes like this: Robert Redus, a student at the University of the Incarnate Word in Alamo Heights, was "driving erratically at a high rate of speed... | multi_news |
H2A. Z is a histone H2A variant conserved from yeast to humans, and is found at 63% of promoters in Saccharomyces cerevisiae. This pattern of localization suggests that H2A. Z is somehow important for gene expression or regulation. H2A. Z can be acetylated at up to four lysine residues on its amino-terminal tail, and a... | Transcriptional memory is the well-documented phenomenon by which cells can "remember" prior transcriptional states. A paradigmatic example of transcriptional memory is found in the yeast Saccharomyces. S. cerevisiae remembers prior transcription of the galactose metabolism gene GAL1. When a gene is transcribed, the DN... | lay_plos |
Manipulation of sex determination pathways in insects provides the basis for a wide spectrum of strategies to benefit agriculture and public health. Furthermore, insects display a remarkable diversity in the genetic pathways that lead to sex differentiation. The silkworm, Bombyx mori, has been cultivated by humans as a... | The sex determination system extremely diverse among organisms including insects in which even each order occupy a different manner of sex determination. The silkworm, Bombyx mori, is a lepidopteran model insect with economic importance. The mechanism of the silkworm sex determination has been in mystery for a long tim... | lay_plos |
Tyrosine kinases are regarded as excellent targets for chemical drug therapy of carcinomas. However, under strong purifying selection, drug resistance usually occurs in the cancer cells within a short term. Many cases of drug resistance have been found to be associated with secondary mutations in drug target, which lea... | Cancers can eventually confer drug resistance to the continued medication. In most cases, mutations occurred in a drug target can attenuate the binding affinity of the drugs. Here, we studied the drug resistance mechanisms of the mutations G2032R in the ROS1 tyrosine kinase in fusion-type NSCLC. It is well known that t... | lay_plos |
The response of a neuronal population over a space of inputs depends on the intrinsic properties of its constituent neurons. Two main modes of single neuron dynamics–integration and resonance–have been distinguished. While resonator cell types exist in a variety of brain areas, few models incorporate this feature and f... | Dynamic gain, the amount by which features at specific frequencies in the input to a neuron are amplified or attenuated in its output spiking, is fundamental for the encoding of information by neural populations. Most studies of dynamic gain have focused on neurons without intrinsic degrees of freedom exhibiting integr... | lay_plos |
Background IAEA is an independent organization affiliated with the United Nations. Its governing bodies include the General Conference, composed of representatives of the 138 IAEA member states, and the 35-member Board of Governors, which provides overall policy direction and oversight. The Secretariat, headed by the D... | The International Atomic Energy Agency's (IAEA) safeguards system has been a cornerstone of U.S. efforts to prevent nuclear weapons proliferation since the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) was adopted in 1970. Safeguards allow IAEA to verify countries' compliance with the NPT. Since the discover... | gov_report |
Senate Votes To End U.S. Support For War In Yemen, Rebuking Trump And Saudi Arabia Enlarge this image toggle caption Zach Gibson/Getty Images Zach Gibson/Getty Images Updated Dec. 13 at 5:21 p.m. ET The Senate voted with support from lawmakers in both parties Thursday to end U.S. military support for Saudi Arabia's war... | The Senate on Thursday sent what the Washington Post described as a historic rebuke to the White House over Saudi Arabia. Actually, it delivered two rebukes. First, senators voted 56-41 to invoke the War Powers Act and demand that the US end its military support of the Saudi-led coalition in the Yemen war, per the Hill... | multi_news |
With her rise in the coming months to chairman and CEO (as Gianopulos, 64, moves into an undefined "strategic role"), Snider, 55, will preside over the second-hottest studio at the 2016 box office (after Disney). Watts, 46, has become the envy of many of her counterparts at rival studios thanks to hits like The Martian... | For the first time, the Hollywood Reporter has put together a list of the 100 most powerful people in entertainment, though it's what Paste Magazine describes as a list "celebrating the accomplishments of... white guys." Only 19 women and 10 people of color make the cut. THR acknowledges the stat- "We won't need social... | multi_news |
Their next and second attempt thereat was more deliberately made, though it was begun on the morning following the singular child's arrival at their home. Him they found to be in the habit of sitting silent, his quaint and weird face set, and his eyes resting on things they did not see in the substantial world. "His fa... | The morning after the boy arrives, Jude and Sue discover he is called Little Father Time because, as he says, he looks so old. Jude and Sue give notice of their wedding and invite Mrs. Edlin, the widow who took care of his aunt, to come. The night before they are to marry, Mrs. Edlin tells a tale about a man hanged nea... | booksum |
15:04 More from Cardiff where Theresa May was booed after attending a Brexit meeting with the heads of the devolved assemblies. steven morris (@stevenmorris20) JMC meeting in Cardiff - small demo outside. Protesters worried about Trump and Brexit. pic.twitter.com/cSg4t74Sum The Scottish first minister, Nicola Sturgeon,... | President Trump's travel ban on citizens of seven countries continued to cause chaos and protests at airports around the country and around the world Sunday, though an administration official insisted it was a "massive success," Reuters reports. The attorneys general of 15 states denounced the Trump order as unconstitu... | multi_news |
Prologue: A large park. The camera pans along some flowery foliage until it reaches a pair of green scaly legs firmly planted to the ground and a pair of human legs dangling and kicking from someone pinned high against a tree. The monster makes gurgling noises and low-pitched roars. Cut to Buffy being held against the ... | Cordelia's pain over Xander's betrayal summons Anyanka ( Emma Caulfield ), a vengeance demon who grants wishes to scorned women. Cordelia wishes that Buffy had never come to Sunnydale, and constructs an alternate reality where the Master ( Mark Metcalf ) rose from the dead and the Harvest took over Sunnydale. Giles dis... | summ_screen_fd |
Background Airline Passenger Screening Using Checkpoint Screening Technology Passenger screening is a process by which screeners inspect individuals and their property to deter and prevent an act of violence or air piracy, such as the carrying of any unauthorized explosive, incendiary, weapon, or other prohibited item ... | The December 25, 2009, attempted bombing of flight 253 raised questions about the federal government's ability to protect the homeland and secure the commercial aviation system. This statement focuses on the government's efforts to use the terrorist watchlist to screen individuals and determine if they pose a threat, a... | gov_report |
Molecular evolution is an established technique for inferring gene homology but regulatory DNA turns over so rapidly that inference of ancestral networks is often impossible. In silico evolution is used to compute the most parsimonious path in regulatory space for anterior-posterior patterning linking two Dipterian spe... | The last common ancestor of the fruit fly (Drosophila) and mosquito (Anopheles) lived more than 200 Million years ago. Can we use available data on insects alive today to infer what their ancestor looked like? In this manuscript, we focus on early embryonic development, when stripes of genetic expression appear and def... | lay_plos |
While sensory neurons carry behaviorally relevant information in responses that often extend over hundreds of milliseconds, the key units of neural information likely consist of much shorter and temporally precise spike patterns. The mechanisms and temporal reference frames by which sensory networks partition responses... | Neurons in sensory cortices encode objects in our sensory environment by varying the timing and number of action potentials that they emit. Brain networks that 'decode' this information need to partition those spike trains into their individual informative units. Experimenters achieve such partitioning by exploiting th... | lay_plos |
FIELD OF THE INVENTION The invention relates to a process for enhancing some of the functional properties of denatured proteinaceous material of vegetable origin. BACKGROUND OF THE INVENTION Vegetable protein products obtained from seed and leaf materials are used as replacements and extenders for proteins derived from... | A process for enhancing the functional properties of denatured proteinaceous material of vegetable origin. The enhanced properties include at least one property selected from the group consisting of water absorption, water binding capacity, oil binding capacity, fat binding capacity, and the ability to produce viscous ... | big_patent |
Recent advances in DNA sequencing have enabled mapping of genes for monogenic traits in families with small pedigrees and even in unrelated cases. We report the identification of disease-causing mutations in a rare, severe, skeletal dysplasia, studying a family of two healthy unrelated parents and two affected children... | Skeletal dysplasias are a group of genetic disorders affecting skeletal development that cause deficiencies and deformities of the limbs and spine, dwarfism, or abnormal bone strength. Skeletal dysplasias are usually inherited as monogenic Mendelian traits or occur as a result of de novo mutations. We report identifica... | lay_plos |
Iron sulfur (Fe/S) proteins are ubiquitous and participate in multiple biological processes, from photosynthesis to DNA repair. Iron and sulfur are highly reactive chemical species, and the mechanisms allowing the multiprotein systems ISC and SUF to assist Fe/S cluster formation in vivo have attracted considerable atte... | Iron sulfur (Fe/S) proteins are found in all living organisms where they participate in a wide array of biological processes. Accordingly, genetic defects in Fe/S biogenesis yield pleiotropic phenotypes in bacteria and several syndromes in humans. Multiprotein systems that assist Fe/S cluster formation and insertion in... | lay_plos |
A fundamental feature of sexual reproduction in plants and animals is the specification of reproductive cells that conduct meiosis to form gametes, and the associated somatic cells that provide nutrition and developmental cues to ensure successful gamete production. The anther, which is the male reproductive organ in s... | The differentiation of distinct somatic and reproductive cells in flowers is required for the successful sexual reproduction of plants. The anther produces reproductive microsporocytes (pollen mother cells) that give rise to pollen (male gametophytes), as well as surrounding somatic cells (particularly the tapetal cell... | lay_plos |
Worldwide, amoebic liver abscess (ALA) can be found in individuals in non-endemic areas, especially in foreign-born travelers. We performed a retrospective analysis of ALA in patients admitted to French hospitals between 2002 and 2006. We compared imported ALA cases in European and foreign-born patients and assessed th... | Amœbiasis is caused by Entamoeba histolytica (E. histolytica), a protozoan specific to humans which infects humans by ingestion of contaminated food and water. According to some authors, amœbiasis could be the second leading cause of death from parasitic disease worldwide. It is endemic in tropical countries but can al... | lay_plos |
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8. 4%. Using a join... | Viral loads of Human Immunodeficiency Virus infections are correlated between the donor and the recipient of the transmission pair. Similarly, human genetic factors may modulate viral load. In this study we estimate the extents to which viral load is heritable either via the viral genotype (from donor to recipient) or ... | lay_plos |
BERKELEY Cocaine can speedily rewire high-level brain circuits that support learning, memory and decision-making, according to new research from UC Berkeley and UCSF. The findings shed new light on the frontal brain’s role in drug-seeking behavior and may be key to tackling addiction. Looking into the frontal lobes o... | Just one dose of cocaine may physically change the brain as the body begins "learning addiction," scientists say. They investigated the effect of the drug on mice, and noted that within two hours of being injected with the drug, brain changes were visible, the BBC reports. After two hours, scans showed that mice on the... | multi_news |
Comedian Bill Cosby adjusts his Presidential Medal of Freedom as baseball great Hank Aaron, left, looks on in a ceremony in the East Room of the White House in 2002. A victims' group called on President Obama to revoke the award to Cosby, which was awarded by President George W. Bush. (Photo: H. DARR BEISER, USA TODAY)... | Bill Cosby's acting career is incredibly unlikely to survive the news that he admitted drugging women before having sex with them, and it looks like his talent agency saw the writing on the wall months ago. CAA, which lured Cosby away from the William Morris agency in 2012, "quietly dumped" him late last year, leaving ... | multi_news |
Haploinsufficiency, wherein a single functional copy of a gene is insufficient to maintain normal function, is a major cause of dominant disease. Human disease studies have identified several hundred haploinsufficient (HI) genes. We have compiled a map of 1,079 haplosufficient (HS) genes by systematic identification of... | Humans, like most complex organisms, have two copies of most genes in their genome, one from the mother and one from the father. This redundancy provides a back-up copy for most genes, should one copy be lost through mutation. For a minority of genes, one functional copy is not enough to sustain normal human function, ... | lay_plos |
The functional effects of most amino acid replacements accumulated during molecular evolution are unknown, because most are not observed naturally and the possible combinations are too numerous. We created 168 single mutations in wild-type Escherichia coli isopropymalate dehydrogenase (IMDH) that match the differences ... | Many bioinformatics and functional genomics predictions are derived from evolutionary patterns of amino acid replacement in protein sequence alignments. Most computational methods assume that replacements in one sequence will be tolerated in all related sequences. Here, we evaluate-by direct experiment-the functional i... | lay_plos |
The tapeworm Taenia solium is the parasite responsible for neurocysticercosis, a neglected tropical disease of public health importance, thought to cause approximately 1/3 of epilepsy cases across endemic regions. The consumption of undercooked infected pork perpetuates the parasite’s life-cycle through the establishme... | Taenia solium is a serious zoonotic helminth which is thought to be responsible for approximately 1/3rd of epilepsy cases in the developing world. The work presented in this paper aimed to understand what the risk is of acquiring T. solium taeniosis from pork slaughtered and consumed in western Kenya. In order to do th... | lay_plos |
Ribosomal RNA gene (rDNA) copy number variation modulates heterochromatin formation and influences the expression of a large fraction of the Drosophila ge-nome. This discovery, along with the link between rDNA, aging, and disease, high-lights the importance of understanding how natural rDNA copy number variation arises... | We show that altering the nutritional medium of Drosophila cultures, emulating dietary largess in the wild, increases expression of the high copy-number ribosomal RNA genes and results in rDNA instability and loss. The reduction in gene copy number occurs both in somatic and germ cells, such that altered copy numbers a... | lay_plos |
We previously reported that the G allele of rs3853839 at 3′untranslated region (UTR) of Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 Eastern Asians [P = 6. 5×10−10, odds ratio (OR) (95%CI) = 1. 27 (1. 17–1. 36) ]. Here,... | Systemic lupus erythematosus (SLE) is a debilitating autoimmune disease contributed to by excessive innate immune activation involving toll-like receptors (TLRs, particularly TLR7/8/9) and type I interferon (IFN) signaling pathways. TLR7 responds against RNA-containing nuclear antigens and activates IFN-α pathway, play... | lay_plos |
An important open problem of computational neuroscience is the generic organization of computations in networks of neurons in the brain. We show here through rigorous theoretical analysis that inherent stochastic features of spiking neurons, in combination with simple nonlinear computational operations in specific netw... | Experimental data from neuroscience have provided substantial knowledge about the intricate structure of cortical microcircuits, but their functional role, i. e. the computational calculus that they employ in order to interpret ambiguous stimuli, produce predictions, and derive movement plans has remained largely unkno... | lay_plos |
The seven-year-old British girl shot, bludgeoned over the head and left for dead by an assailant who murdered her parents has regained consciousness in a French hospital. Doctors had placed Zainab al-Hilli, who police hope holds the key to the mysterious assassination, in a medically induced coma to aid her recovery. R... | A new detail in this week's multiple murder in the French Alps: Saad al-Hilli, who was gunned down with his wife and mother, had written a letter calling his brother a "control freak" who should be wiped "out of my life." Saad and brother Zaid clashed over their father's assets, and Zaid and "demanded control," wrote S... | multi_news |
This is the shocking moment three armed raiders threatened Domino's Pizza staff with a knife and guns before making off with cash - in a raid which lasted less than 60 seconds. The men stormed into the takeaway in Corby, Northamptonshire, after pulling up outside the entrance in a red Saab. CCTV footage shows the maske... | CCTV footage shows three robbers entering pizza outlet in Corby, Northamptonshire. The masked men are seen pulling up outside Domino's Pizza in red Saab. They burst into the store before diving over counter and rounding up staff. One terrified worker was grabbed around neck and threatened with a knife. Another raider t... | cnn_dailymail |
In the city of Brotherly Love, the home of Rocky Balboa, the place where disgruntled Eagles fans once booed Santa Claus, the increasingly personal and bitter fight for the Democratic nomination took a sharp pugilistic turn Wednesday night. The issue: whether either candidate is even fit for the White House. Hillary Cli... | Suddenly, it's the Democratic race making headlines for fireworks between the candidates. On Wednesday, Bernie Sanders said Hillary Clinton isn't "qualified" to be president-and ticked off several reasons to make his case, reports CNN. In response, the Clinton campaign said he had reached a "new low." In a speech at Te... | multi_news |
[School Gym]
(Annual Boy Toy Auction)
WHITEY: Come on, let's get those bids up, it's the Annual Boy Toy Auction. Alright I've got $25, do I hear $40? Oh come on people, this is for charity. $40?
GIRL1: $40
WHITEY: $40. Coming up right there. Anybody got $50? How about $50? $50?
GIRL2: $50
WHITEY: $50. And remember for ... | Lucas, Nathan and Jake are auctioned off to the highest bidder in the annual "Boy Toy" charity auction and the night leads to surprising developments with old flames. Meanwhile, having missed out on the auction, Brooke ends up spending the night with Mouth and he has the time of his life. This episode is named after a ... | summ_screen_fd |
Virus-like particles (VLPs) have not been observed in Caenorhabditis germ cells, although nematode genomes contain low numbers of retrotransposon and retroviral sequences. We used electron microscopy to search for VLPs in various wild strains of Caenorhabditis, and observed very rare candidate VLPs in some strains, inc... | Retrotransposons and retroviruses pose enormous threats to animal and plants because of their ability to insert into host genes. Retroelements that replicate in germ cells can, if left unchecked, expand exponentially in the host genome. C. elegans has proven to be an exceptional model system for studying many facets of... | lay_plos |
Recent experimental evidence suggests that coordinated expression of ion channels plays a role in constraining neuronal electrical activity. In particular, each neuronal cell type of the crustacean stomatogastric ganglion exhibits a unique set of positive linear correlations between ionic membrane conductances. These d... | Most motor neurons receive input from the brain before transmitting to the muscle, resulting in a muscle contraction. In some cases, a small group of motor neurons can act independently to control rhythmic muscle contractions. Locomotion in mammals is thought to arise, in a large part, due to neuronal networks of this ... | lay_plos |
The pupil is primarily regulated by prevailing light levels but is also modulated by perceptual and attentional factors. We measured pupil-size in typical adult humans viewing a bistable-rotating cylinder, constructed so the luminance of the front surface changes with perceived direction of rotation. In some participan... | The pupils control how much light reaches the eye. They become smaller in bright light and larger in darkness to let more light in. Other factors can also affect pupil size. For example, the pupils slightly constrict when a person focuses on brighter objects and they enlarge when focusing on a darker object. Tracking c... | lay_elife |
This is a continuation of application Ser. No. 343,779, filed Mar. 22, 1973, now abandoned. BACKGROUND OF THE INVENTION 1. Field of the Invention The invention concerns a respirator and more particularly a respirator in which flow and pressure of the respiration gas are automatically regulated during inspiration and ex... | A respirator used to replace or assist the respiratory function and automatically regulate the respiration gas flow and pressure during the inspiration phase and expiration phase comprising means for measuring the flow and pressure of respiration gas and providing electrical output signals, valve means including an adj... | big_patent |
SECTION 1. SHORT TITLE. This Act may be cited as the ``Subsidized Stafford Loan Reduced Interest Rate Extension Act of 2012''. TITLE I--EXTENSION OF REDUCED INTEREST RATE SEC. 101. INTEREST RATE EXTENSION. Section 455(b)(7)(D) of the Higher Education Act of 1965 (20 U.S.C. 1087e(b)(7)(D)) is amended-- (1) in the matter... | Subsidized Stafford Loan Reduced Interest Rate Extension Act of 2012 - Amends title IV (Student Assistance) of the Higher Education Act of 1965 to make the 3.4% interest rate on Direct Stafford loans first disbursed to undergraduate students between July 1, 2011, and July 1, 2012, applicable to Direct Stafford loans fi... | billsum |
Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants near the LRRK2 gene have been a... | A major challenge of current leprosy control is the management of host pathological immune responses coined Type-1 Reactions (T1R). T1R are characterized by acute inflammatory episodes whereby cellular immune responses are directed against host peripheral nerve cells. T1R affects up half of all leprosy patients and are... | lay_plos |
SECTION 1. SHORT TITLE; TABLE OF CONTENTS. (a) Short Title.--This Act may be cited as the ``Paul Revere Freedom to Warn Act''. (b) Table of Contents.--The table of contents for this Act is as follows: Sec. 1. Short title; table of contents. Sec. 2. Discrimination against whistleblowers prohibited. Sec. 3. Enforcement a... | Paul Revere Freedom to Warn Act - Makes it unlawful to take any adverse personnel action against any covered individual if such individual has acted lawfully to: (1) provide information or assistance in an investigation or proceeding regarding any conduct which the covered individual reasonably believes constitutes evi... | billsum |
A man has been convicted of rape after the victim spotted him six years after the incident, according to Fulton County prosecutors. Antonio White, 54, was sentenced to life without parole after he was convicted Friday night, Fulton County District Attorney Paul Howard said in a statement. The victim recognized White wh... | A woman raped in 2007 had the jarring experience of spotting her rapist six years later in an Atlanta subway station, reports the Atlanta Journal Constitution. At that point, she didn't think much about what to do next. "She was overcome by the moment and began to yell out that he was the man who had raped her six year... | multi_news |
TECHNICAL FIELD OF INVENTION [0001] This invention relates to control methods to use in Plant health management programs. Provides an active ingredient and a method of biological control against diseases caused by the root-knot-nematodes that belong to the genera Meloidogyne spp. In this particular form provides a stra... | This invention refers to isolation and utilization of the fungus Pochonia chlamydosporia var. chlamydosporia strain PcMR in biological control of nematodes, characterized in that it has a high virulence against Meloidogyne spp. in in-vitro microbiologic tests, pot tests and field tests. In these tests, the strain PcMR,... | big_patent |
Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working memory in a multicenter, randomi... | Exercise has beneficial effects on the body and brain. People who perform well on tests of cardiovascular fitness also do well on tests of learning, memory and other cognitive skills. So far, studies have suggested that moderate intensity aerobic exercise that lasts for 30 to 40 minutes produces the greatest improvemen... | lay_elife |
For the Record: For Trump, everything’s going to be alt-right Donald Trump gives a thumbs-up following his speech during a campaign rally in Austin, Texas, on Aug. 23, 2016. (Photo: Suzanne Cordeiro, AFP/Getty Images) On Thursday, the term “alt-right” entered the 2016 spotlight like never before. First, Hillary Clinton... | Suddenly, "alt-right" is the political phrase of the moment. Hillary Clinton on Thursday called out Donald Trump for being linked to what she calls a racist, "paranoid fringe" movement, while Trump denied even knowing what the phrase means. Coverage: What Clinton said, per Gothamist: "These are race-baiting ideas, anti... | multi_news |
SECTION 1. SHORT TITLE. This Act may be cited as ``The Separate Enrollment and Line Item Veto Act of 1999''. SEC. 2. STRUCTURE OF LEGISLATION. (a) Appropriations Legislation.-- (1) In general.--The Committee on Appropriations of either the House or the Senate shall not report an appropriation measure that fails to cont... | Separate Enrollment and Line Item Veto Act of 1999 - Prohibits the Committee on Appropriations of either the House of Representatives or the Senate from reporting an appropriation measure that fails to contain such level of detail on the allocation of an item of appropriation proposed by that House as is set forth in t... | billsum |
(CNN) -- A Delaware pediatrician was indicted Wednesday on 58 additional counts of rape and other sexual offenses in the alleged child abuse of his patients, state Attorney General Beau Biden announced Monday. Dr. Earl Bradley, 56, previously pleaded not guilty to 471 felony counts involving 102 girls and one boy. Wedn... | A Delaware pediatrician charged with sexually assaulting more than 100 of his small patients has been hit with another 58 counts of sex offenses, reports CNN, boosting the total against him to a record 529 charges. Dr. Earl Bradley, 56, has pleaded not guilty to 471 felony counts involving sex assaults on 102 girls and... | multi_news |
The dominance of the major transcript isoform relative to other isoforms from the same gene generated by alternative splicing (AS) is essential to the maintenance of normal cellular physiology. However, the underlying principles that determine such dominance remain unknown. Here, we analyzed the physical AS process and... | Alternative RNA splicing within eukaryotic cells enables each gene to generate multiple different mature transcripts which further encode proteins with distinct or even opposing functions. The relative frequencies of the transcript isoforms generated by a particular gene are essential to the maintenance of normal cellu... | lay_plos |
Abstract Background Previous studies have shown that young fatherhood is associated with higher later-life mortality. It is unclear whether the association is credible, in the sense that mortality and young fatherhood appear to be associated because both are determined by family-related environmental, socioeconomic and... | The younger men are when they become fathers, the more likely they are to die by their 40s or 50s, according to a large new study out of Finland. Researchers say they've seen this link before, but wanted to test it using brothers who share similar DNA to better control for genetic and environmental differences, reports... | multi_news |
Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helminth infections induce polarised Th2 responses that may impair HIV vacc... | Chronic parasitic worm infections are thought to reduce the efficacy of vaccines. Given that HIV and worm infections are common in sub-Saharan Africa (SSA) and their geographical distribution vastly overlaps, it is likely that future HIV vaccines in SSA will be administered to a large proportion of people with chronic ... | lay_plos |
[PREVIOUSLY_ON]
Rebekah: Hello, Nik.
Klaus: (gapes at her, clearly shocked, but eventually smiles) Rebekah.
Freya: You know who I am.
Rebekah: Freya.
Freya: Tell our brothers I'll be coming to see them soon.
Mary: Do you renounce your Alpha status?
Hayley: These attacks, they're only gonna get worse. We need to get mar... | Cami rushes away from the house and stops at a payphone where Elijah meets her and Hope. Klaus offers his house for the location of Jackson and Hayley's wedding. Just before the wedding Elijah and Cami arrive at the house and Hope is reunited with her parents. Hayley doesn't want Elijah to change her mind about the wed... | summ_screen_fd |
Scene: Sheldon and Leonard's apartment.
Sheldon: I've been thinking about time travel again.
Leonard: Why, did you hit a roadblock with invisibility?
Sheldon: Put it on the back burner. Anyway, it occurs to me, if I ever did perfect a time machine, I'd just go into the past and give it to myself, thus eliminating the n... | At the university Sheldon is fired from his job as a physicist after insulting his new boss Dr. Eric Gablehauser. Sheldon's change of circumstance triggers a downward spiral of depression in which he fails to improve scrambled eggs, develops luminous fish for nightlights, and weaves on a hand loom. Worried, Leonard cal... | summ_screen_fd |
Existing theories of movement planning suggest that it takes time to select and prepare the actions required to achieve a given goal. These theories often appeal to circumstances where planning apparently goes awry. For instance, if reaction times are forced to be very low, movement trajectories are often directed betw... | Two critical processes need to occur before a movement can be made: identification of the goal of the movement and selection and preparation of the motor commands that will be sent to muscles to generate the movement-in other words, what movement to make, and how to make it. It has long been thought that preparing moto... | lay_plos |
Scene: The University cafeteria
Raj: Here's what I wonder about zombies. (Others all groan) What happens if they can't get any human flesh to eat? They can't starve to death, they're already dead.
Howard: You take this one. I spent an hour last night on how do vampires shave when they can't see themselves in the mirror... | President Siebert invites the men to a fundraising event at Caltech. While Leonard, Howard and Raj are willing to attend, Sheldon feels that such events are beneath him. He changes his mind when Amy points out that, without his participation, any monies raised might go to programs other than physics. When he finally ar... | summ_screen_fd |
This article is about the plant that is a symbol of Ireland. Many places, organisations, businesses, products, creative works etc. use the shamrock in their names. For other uses, see Shamrock (disambiguation) Not to be confused with four-leaf clover A shamrock A shamrock is a young sprig, used as a symbol of Ireland. ... | We all know what a shamrock looks like, but-speaking in scientific terms-just what is it? A clover? A wood sorrel? Some other type of plant? Unfortunately, there's no single answer: The shamrock is the stuff of legend, not science, the Smithsonian reports. Over the centuries, a number of different plants have been call... | multi_news |
The binding of proteins can shield DNA from mutagenic processes but also interfere with efficient repair. How the presence of DNA-binding proteins shapes intra-genomic differences in mutability and, ultimately, sequence variation in natural populations, however, remains poorly understood. In this study, we examine sequ... | Mutations can be more or less likely to occur depending on whether DNA is naked or bound by proteins. On the one hand, DNA-binding proteins can shield the DNA from certain mutagenic processes. On the other hand, the very same proteins can interfere with efficient DNA repair. In this study, we reconstruct the history of... | lay_plos |
By. Sarah Dean. An Australian jihadist has sent sickening threats against his former country after a warrant was issued for his arrest by the Australian Federal Police. Mohamed Elomar and Khaled Sharrouf, from Sydney, are fighting with al-Qaeda off-shoot Islamic State of Iraq and the Levant, in Syria, and will be arres... | Khaled Sharrouf and Mohamed Elomar have warrants out for their arrests. Sharrouf posted a photo of Elomar holding up severed heads. Elomar has now threatened Australia with a terrorist attack. He's the brother of Ahmed Elomar, jailed in June for bashing police officer. Mohamed Elomar has a wife and four children in Syd... | cnn_dailymail |
Angus T. Jones, the "Two and a Half Men" actor who dismissed his show as "filth" and begged people to stop watching, has found another supporter -- and possibly a new gig -- in Charlie Sheen. "My former nephew is welcome at the Goodson Anger Management home anytime," Sheen told ABCNews.com, inviting Jones to appear on ... | Not surprisingly, Angus T. Jones probably won't return to Two and a Half Men, which he recently referred to as "filth," if the show is renewed for an 11th season, sources confirm to E!. His character-the "half" referred to in the title-joined the Army at the end of season nine and hasn't been in many episodes this seas... | multi_news |
CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of Postal et al. U.S. application Ser. No. 09/288,764, filed Apr. 8, 1999 now U.S. Pat. No. 6,247,931 B1 which is a continuation-in-part of Postal et al. U.S. application Ser. No. 08/878,995, filed Jun. 19, 1997, now U.S. Pat. No. 5,931,... | A transmission for changing rotary motion into angularly reciprocating motion and adapted to be mounted on the output end of a dental power unit of the type having a rotary drive output and used to drive a dental tool. The transmission is comprised of a support member, a driving resinous member supported by the support... | big_patent |
SECTION 1. SHORT TITLE. This Act may be cited as the ``Stop Trading on Congressional Knowledge Act''. SEC. 2. NONPUBLIC INFORMATION RELATING TO CONGRESS. (a) Securities Transactions.--Section 10 of the Securities Exchange Act of 1934 is amended by adding at the end the following: ``(c) Nonpublic Information Relating to... | Stop Trading on Congressional Knowledge Act - Amends the Securities Exchange Act of 1934 and the Commodities Exchange Act to direct both the Securities and Exchange Commission (SEC) and the Commodity Futures Trading Commission (CFTC) to prohibit purchase or sale of either securities or commodities for future delivery b... | billsum |
SECTION 1. SHORT TITLE; TABLE OF CONTENTS. (a) Short Title.--This Act may be cited as the ``Hunting, Education, and Recreational Development Act'' or the ``HEARD Act''. (b) Table of Contents.--The table of contents for this Act is: Sec. 1. Short title; table of contents. Sec. 2. Findings and purpose. Sec. 3. Definition... | Hunting, Education, and Recreational Development Act or the HEARD Act This bill authorizes the Department of the Interior and the Department of Agriculture (USDA) to dispose of federal lands under their respective jurisdictions by offering them for sale or exchange to units of local government in accordance with this b... | billsum |
(CNN) The shooting of Rep. Steve Scalise and four others at a baseball practice for Republican members of Congress on Wednesday morning in Alexandria, Virginia, was always going to quickly turn to politics. Rep. Chris Collins, one of President Donald Trump's most prominent congressional supporters, insisted that the sh... | James Hodgkinson, the 66-year-old Illinois man police say shot and wounded multiple people during a GOP congressional baseball practice Wednesday, was a former volunteer for the Bernie Sanders campaign, Politico reports. Sanders condemned the shooting "in the strongest possible terms," calling it a "despicable act." "V... | multi_news |
ROCHESTER, N.H. (AP) — Journalist James Foley had worked in a number of conflict zones in the Middle East, but the danger didn't stop him from doing the job he loved. A ribbon is tied to a tree outside the home of American freelance journalist James Foley, on Tuesday Aug. 19, 2014, in Rochester, N.H. A video by Islamic... | The mother of the American journalist beheaded by ISIS has urged the militant group to free other Americans it has threatened to kill. "We have never been prouder of our son Jim. He gave his life trying to expose the world to the suffering of the Syrian people," Diane Foley writes in a post at the Free James Foley Face... | multi_news |
Angel: "You've had vision."
Cordy: "Boy! Howdy! - Doyle kissed me just before he died and he passed it on to me!" Cordy in her new apartment..
Cordy: "I'm not giving up this apartment!"
Angel: "It's haunted!"
Cordy: "It's rent controlled!" Cordy talking to Aura in the phone: "Yeah, I have a room-mate, but it's cool. I ... | After sleeping with a photographer she had seen a few times, Cordelia wakes up to find herself extremely pregnant; she and several other women are carrying the spawn of a Haxil Beast that uses men as sexual surrogates. Angel and Wesley must find a way to break the demon's psychic control over its human incubators befor... | summ_screen_fd |
Forty-two years after founding one of the nation’s most influential evangelical megachurches, the Rev. Bill Hybels told his congregation Tuesday night that he would step down from the helm of Willow Creek Community Church six months ahead of schedule. His departure comes less than a month after a Chicago Tribune invest... | A pastor and former spiritual adviser to President Clinton has stepped down from one of the largest evangelical churches in the country over allegations of misconduct with women. Bill Hybels, 66, planned to retire from the Chicago-area megachurch he founded 43 years ago in October. But at Willow Creek's Tuesday service... | multi_news |
TECHNICAL FIELD [0001] This application relates in general to a method, apparatus, and article of manufacture for providing adaptive medical therapies utilizing a neural network based learning engine, and more particularly to a method, apparatus, and article of manufacture for implementing an implantable cardiac device... | A cardiac device system for implementing a cardiac device having adaptive treatment therapies utilizing a neural network based learning engine includes an implantable cardiac device module and an external data processing system for specifying the operating characteristics of the cardiac device module. Both the cardiac ... | big_patent |
Mycobacterial pathogens are the causative agents of chronic infectious diseases like tuberculosis and leprosy. Autophagy has recently emerged as an innate mechanism for defense against these intracellular pathogens. In vitro studies have shown that mycobacteria escaping from phagosomes into the cytosol are ubiquitinate... | Tuberculosis is a serious infectious disease that claims over a million lives annually. Vaccination provides insufficient protection and the causative bacterial pathogen, Mycobacterium tuberculosis, is becoming increasingly resistant to antibiotic therapy. Therefore, there is an urgent need for novel therapeutic strate... | lay_plos |
Introduction North Korea's systematic violation of its citizens' human rights and the plight of North Koreans trying to escape their country have been well documented in multiple reports issued by governments and other international bodies. The Bush Administration initially highlighted and later de-emphasized Pyongyang... | As the incoming Obama Administration conducts a review of U.S. policy toward North Korea, addressing the issue of human rights and refugees remains a priority for many members of Congress. The passage of the reauthorization of the North Korean Human Rights Act in October 2008 (P.L. 110-346) reasserted congressional int... | gov_report |
Photo Elon Musk, the chief executive of Tesla Motors, has now responded in detail to the account of my test drive of his Model S electric car, using the company’s new East Coast Superchargers, that was published in The Times on Feb. 10. His broadest charge is that I consciously set out to sabotage the test. That is not... | A New York Times auto reviewer has issued a point-by-point rebuttal to Tesla's claims that he deliberately set out to make the Model S electric car look bad. In one of the standout accusations, based on the car's driving logs, Tesla's Elon Musk wrote that John Broder "drove in circles for over half a mile in a tiny, 10... | multi_news |
Understanding the theoretical foundations of how memories are encoded and retrieved in neural populations is a central challenge in neuroscience. A popular theoretical scenario for modeling memory function is the attractor neural network scenario, whose prototype is the Hopfield model. The model simplicity and the loca... | Recurrent neural networks have been shown to be able to store memory patterns as fixed point attractors of the dynamics of the network. The prototypical learning rule for storing memories in attractor neural networks is Hebbian learning, which can store up to 0. 138N uncorrelated patterns in a recurrent network of N ne... | lay_plos |
Drug resistance represents one of the main problems for the use of chemotherapy to treat leishmaniasis. Additionally, it could provide some advantages to Leishmania parasites, such as a higher capacity to survive in stress conditions. In this work, in mixed populations of Leishmania donovani parasites, we have analyzed... | Chemotherapy is currently the only treatment option for leishmaniasis, a neglected tropical disease produced by the protozoan parasite Leishmania. However, first-line drugs have different types of limitations including toxicity, price, efficacy and mainly emerging resistance. The WHO has recently recommended a combined... | lay_plos |
This invention relates generally to surgical instruments and surgical techniques and, more particularly, to eye surgery and to phacoemulsification apparatus and methods for their use. This application is a continuation-in-part application of application Ser. No. 11/069,773, filed Mar. 1, 2005, which claims priority fro... | An irrigation and aspiration tubing system for use with surgical handpieces and irrigation fluid supplies has a flexible tube with first and second lumens formed integrally along its length, with a first lumen used for transporting irrigation fluid to the handpiece and a second lumen used for aspiration of fluid and em... | big_patent |
High-throughput RNA sequencing enables quantification of transcripts (both known and novel), exon/exon junctions and fusions of exons from different genes. Discovery of gene fusions–particularly those expressed with low abundance– is a challenge with short- and medium-length sequencing reads. To address this challenge,... | Advances in sequencing technology are enabling detailed characterization of RNA transcripts from biological samples. The fundamental challenge of accurately mapping the reads on transcripts and gleaning biological meaning from the data remains. One class of transcripts, gene fusions, is particularly important in cancer... | lay_plos |
To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and mitochondrial genomes. How an effective stoichiometry of this many constituent subunits is co-ordinated post-transcriptionally remains poorly understo... | Animal cells generate over 90% of the energy they need within small structures called mitochondria. Converting food into energy requires many different proteins and cells control the relative amounts of the proteins in mitochondria to ensure this process is efficient. To make more of a given protein, the cell must copy... | lay_elife |
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