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values | title stringlengths 18 299 | brief_summary stringlengths 43 4.98k | eligibility stringlengths 215 14.3k | date_of_extraction date32 |
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NCT06307496 | Not yet recruiting | VIDeOS for Smoking Cessation | The purpose of the current study is to pilot the efficacy, feasibility, and acceptability of an evidence-based smoking cessation intervention adapted for cancer patients and delivered via video. Investigators aim to assess if this intervention is considered acceptable by participants, feasible to implement, and effecti... | - EligibilityCriteria: Inclusion Criteria: Age 18 or older Diagnosed with cancer (any type) Receiving care at Medical University of South Carolina Reads and understands English language Currently smoking cigarettes (any amount) Exclusion Criteria: - Unstable or poorly managed medical or psychiatric conditions that i... | 2024-03-12 |
NCT06307470 | Not yet recruiting | Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors | The goal of this clinical trial is to test the efficacy of a nurse-led psychoeducational sexual health intervention for young women breast cancer survivors. The main questions it aims to answer are:
What is the feasibility of this intervention in an online, private setting?
What is the effect of this intervention on r... | - EligibilityCriteria: Inclusion Criteria: Diagnosed with breast cancer (stages I - III) between ages 18 - 50 Completed active treatment (chemotherapy and/or radiation) within the last five years Can read/speak English Access to talk in quiet, safe environment for privacy On hormonal therapies (aromatase inhibitors, t... | 2024-03-12 |
NCT06307457 | Not yet recruiting | A Study of HR+/HER2- Metastatic Breast Cancer Patients Treated With Palbociclib Together With an Aromatase Inhibitor From 2017 to 2023 in Denmark. | The purpose of this study is to describe the effect of the medicine palbociclib when given together with an aromatase inhibitor for treatment of breast cancer. The study will consider participants who:
have advanced or metastatic breast cancer that is spread to other parts of the body.
have HR+/HER2- (hormone recepto... | - EligibilityCriteria: Inclusion Criteria: Patients with breast cancer (ICD-10: C50) A diagnosis of HR+/HER2- locally advanced or metastatic breast cancer Endocrine sensitive, endocrine resistant, or de novo mBC patient Inclusion date: Date of relapse/stage IV disease/progression leading to initiation of palbociclib+A... | 2024-03-12 |
NCT06307444 | Not yet recruiting | Ultrasound-Guided Erectro Spinae Plane Block Versus Stellate Ganglion Block for Patients With Upper Limb Acute Herpes Zoster Pain. | Herpes zoster (HZ) is a painful, eruptive, viral condition results from reactivation of the latent varicella zoster virus after the primary infection. The selection of an effective analgesic method in the acute phase of herpes zoster can decrease the incidence of postherpetic neuralgia by reducing neural sensitization.... | - EligibilityCriteria: Inclusion Criteria: patients over the age of 21 with upper limb herpetic eruption lasting shorter than a week along with moderate to severe pain who got adequate antiviral medications Exclusion Criteria: We will exclude patients who refuse to participate, those who are taking anticoagulant med... | 2024-03-12 |
NCT06307431 | Not yet recruiting | A Study of Adjuvant V940 and Pembrolizumab in Renal Cell Carcinoma (V940-004) | The primary objective of the study is to compare V940 plus pembrolizumab to placebo plus pembrolizumab with respect to disease-free survival (DFS) as assessed by the investigator. The primary hypothesis is that V940 plus pembrolizumab is superior to placebo plus pembrolizumab with respect to DFS. | - EligibilityCriteria: Inclusion Criteria: Has histologically or cytologically confirmed diagnosis of renal cell carcinoma (RCC) with clear cell or papillary histology. Has intermediate-high-risk, high-risk, or M1 no evidence of disease (NED) RCC as defined by the following pathological tumor-node metastasis and tumor... | 2024-03-12 |
NCT06307418 | Not yet recruiting | Internet-based Support for Informal Caregivers of Patients With Head and Neck Cancer - Carer eSupport | The aim of this randomized controlled trial is to investigate the effects of internet-based support (Carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer. The main question[s] it aims to answer are:
What are the effects of internet-based support on informal caregi... | - EligibilityCriteria: Inclusion Criteria: Informal caregivers who have been identified as an informal caregiver by a patient who have consented to that the informal caregivers is approached. Informal caregivers of patients with head and neck cancer who are about to start radiotherapy or have undergone at most five ra... | 2024-03-12 |
NCT06307405 | Not yet recruiting | The Value of mNGS in Diagnosis of Pulmonary Infection | Retrospective analysis of clinical data from 50 hospital-admitted patients with suspected pulmonary infection (as judged by clinical manifestations and imaging findings) was performed on study participants who had collected two different samples of alveolar lavage fluid (BALF) and sputum and underwent metagenomic next ... | - EligibilityCriteria: Inclusion Criteria: Inclusion criteria: Patients meeting diagnostic criteria for pulmonary infection between January 1, 2020 and October 31, 2023. Patients with pulmonary infection were diagnosed with new or worsening focal or diffuse infiltrating lesions on chest CT accompanied by at least one ... | 2024-03-12 |
NCT06307392 | Not yet recruiting | Bougie Versus Endotracheal Tube Alone on First-attempt Intubation Success in Prehospital Emergency Intubation (BETA Trial) | Emergency intubation is routinely performed in the prehospital setting. Airway management in the prehospital setting has substantial challenges, such as hostile environment or lack of technical support in case of first attempt intubation failure, and inherent risk of complications, such as hypoxemia, aspiration or oeso... | - EligibilityCriteria: Inclusion Criteria: Managed by a physician staffed mobile intensive care unit (MICU). With an indication of emergency prehospital endotracheal intubation. Exclusion Criteria: Pregnant women Patients with a "not to be resuscitated" indication. Patients with predictors of difficult intubation (t... | 2024-03-12 |
NCT06307379 | Recruiting | Patient Reported Outcome and Experience Measures for Bronchoscopic Procedures | 'Patient-reported outcomes' (PROMS) and 'patient-reported experiences' (PREMS) are increasingly important parameters in evaluating and adjusting clinical procedures and strategies in healthcare.
Validated disease-specific PROMS related to bronchoscopic procedures are not available and examples in the medical literatur... | - EligibilityCriteria: Inclusion Criteria: Age above 18 years Patient referred for diagnostic flexible bronchoscopy Procedure performed in outpatient setting Exclusion Criteria: Patient unable to adequately respond to the contents of the patient questionnaire. Procedure performed in hospitalised setting Patient with... | 2024-03-12 |
NCT06307366 | Not yet recruiting | Perceptions and Experiences of (Family Members of) People With Mental Illness About the Chance for Mental Illness in (Future) Children, and Needs for Care and Research | Despite consistent evidence that mental illness runs in families, intergenerational transmission of risk of mental illness is rarely considered in clinical practice. Neither preventive programs for children of parents with mental illness are usually implemented in care, nor supportive programs for parenting. Furthermor... | - EligibilityCriteria: Inclusion Criteria: Having (a partner or relative with) a diagnosis of a mental illness in the mood-psychosis spectrum, i.e., psychotic disorder, bipolar disorder, or severe depression At least 18 years old Exclusion Criteria: Insufficient proficiency of the Dutch language No demonstration of ... | 2024-03-12 |
NCT06307353 | Not yet recruiting | Trends of Contraception Methods in Urban Medical Center in el_Balyana | family planning is avital primary Health care intervention that saves lives of mothers and infants empowers women and support their choices regarding their health public life and additional education .In addition family planning is considered as a short term intervention to limit population growth and manage overpopula... | - EligibilityCriteria: Inclusion Criteria: - currently married woman in the child bearing period (15_49) years old attending El_Balyana urban medical Center Exclusion Criteria: women who are divorced or widowed or beyond age of fertility will be excluded - - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Fe... | 2024-03-12 |
NCT06307340 | Not yet recruiting | Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations | During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START Treatment and Recovery centers) in New York City for use among individuals engaged in stimulan... | - EligibilityCriteria: Inclusion Criteria: must be 18 years or older, be a patient at the START clinic receiving methadone for treatment of opioid use disorder, self-report 10+ days of co-use of cocaine and illicit opioids in the past 30-days, meet the criteria for stimulant use disorder (cocaine type; mild, moderate ... | 2024-03-12 |
NCT06307327 | Recruiting | Comparative Study of New Classification and Traditional Classification of Radioactive Oropharyngeal Mucositis | Radiation oropharyngeal mucositis is one of the most painful side effects of radiotherapy in patients with head and neck tumors. However, the traditional radioactive oropharyngeal mucositis grading system has the problem of poor evaluation consistency. To solve this problem, we innovatively classify radiation oropharyn... | - EligibilityCriteria: Inclusion Criteria: Voluntarily sign informed consent; Age 18 or older on the date of signing the informed consent; Histologically confirmed head and neck tumor, radiotherapy or chemoradiotherapy. Exclusion Criteria: They also have other uncontrolled serious medical conditions, such as unstabl... | 2024-03-12 |
NCT06307314 | Recruiting | Plasma SAA1 Levels in Predicting Response to Radiotherapy-induced Oral Mucositis | Head and neck squamous cell carcinoma (SCC) is the sixth most common cancer worldwide, with more than 700,000 new cases and more than 350,000 deaths each year. At present, radiotherapy is an important measure to control the recurrence of head and neck tumors, but almost all patients with head and neck squamous cell car... | - EligibilityCriteria: Inclusion Criteria: Over 18 years of age. Voluntarily sign informed consent. The pathological diagnosis was nasopharyngeal carcinoma, head and neck tumor. Need to be treated with radiotherapy. ECOG PS Score: 0/1. Exclusion Criteria: There are contraindications to radiotherapy. Combined with ot... | 2024-03-12 |
NCT06307275 | Recruiting | Intermittent Fasting on Body Fat and Quality of Life | The purpose of this investigator-initiated study to check the feasibility that intermittent fasting has on body fat loss and quality of life. | - EligibilityCriteria: Inclusion Criteria: • In good health Exclusion Criteria: • Diabetes or Metabolic Syndrome - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult | 2024-03-12 |
NCT06307262 | Recruiting | European Registry of Transcatheter Repair for Tricuspid Regurgitation | To investigate clinical and survival outcomes following transcatheter tricuspid valve repair or replacement. | - EligibilityCriteria: Inclusion Criteria: Patients treated with one of the following transcatheter devices for TV repair or replacement (e.g. PASCAL, TriClip, TricValve, Evoque, LuX-Valve) Exclusion Criteria: Age < 18 years - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adul... | 2024-03-12 |
NCT06307249 | Recruiting | Precision Therapy for Solid Tumors: Synergistic CDK4/6 Inhibition and Anti-VEGF Targeting LncRNA | Solid tumors pose significant challenges in current therapeutic approaches. Targeted therapy has emerged as a promising avenue, aiming to enhance treatment efficacy while minimizing adverse effects. This clinical trial focuses on an innovative combination of two targeted inhibitors, Palbociclib and Bevacizumab, for the... | - EligibilityCriteria: Inclusion Criteria: Individuals of white ethnicity. Age between > 18 Both males and females. Diagnosis of selected cancer type (e.g., colorectal cancer, lung cancer, genitourinary cancers, breast cancer). Cancer stage III/ IV with or without metastasis or lymph node dissemination at the time of ... | 2024-03-12 |
NCT06307197 | Recruiting | HAAL: HeAlthy Ageing Eco-system for peopLe With Dementia | HAAL project aims to test several technological devices in order to improve the quality of life of older people with dementia and their informal and formal caregiver. | - EligibilityCriteria: Inclusion Criteria: being the caregiver of a person with cognitive impairment or dementia; availability of time to participate; visit the assisted person at least two times at week or live with him/her. Exclusion Criteria: Lack of written informed consent - HealthyVolunteers: No - Gender: All ... | 2024-03-12 |
NCT06307184 | Recruiting | Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer | This study will assess the convenience of the natural proliferative phase frozen embryo transfer (NPP-FET) in terms of number of number of appointments needed before cycle scheduling. | - EligibilityCriteria: Inclusion Criteria: Endometrial thickness ≥ 7 mm on the day of starting progesterone-based luteal phase support (LPS) Serum progesterone levels <1.5 ng/ml on the day of starting progesterone-based LPS LPS with micronized progesterone 400mg b.i.d. Regular cycles (>24 days, ≤ 38 days) IVF/ICSI wit... | 2024-03-12 |
NCT06307171 | Recruiting | Human Leishmaniasis: Antigen Recognition Pattern and Study of New Potential Biomarkers | This is an exploratory experimental multicentre study on archived serum samples and on prospectively collected serum samples and blood samples.
General objectives of the study are: to identify specific biomarkers in order to develop more accurate serological tests for the screening of Leishmania infections that does n... | - EligibilityCriteria: CASES: Inclusion criteria: Leishmania positive patient from Italy (n=30) and from Sudan (n=30); patient with a clinically or laboratory confirmed diagnosis of leishmaniasis; signed informed consent (criteria not applied in case of samples stored at the Tropica Biobank at the DITM) being clinica... | 2024-03-12 |
NCT06307080 | Recruiting | Clinical Study of Multi-mode Thermal Ablation for the Treatment of Pancreatic Cancer With Liver Metastasis | Clinical evaluation of multimodal ablation system for pancreatic cancer with hepatic metastatic malignancies.
Construction of a combined treatment system of multimodal ablation therapy combined with immunotherapy and chemotherapy.
Transformation and clinical application of multimodal ablation system for pancreatic canc... | - EligibilityCriteria: Inclusion Criteria: age 18-70 years old, gender is not limited; Newly diagnosed pancreatic cancer with liver metastasis confirmed by pathology or consistent with clinical diagnosis, and no metastases to organs other than the liver; Imaging evaluable tumors with safe access to puncture; The numbe... | 2024-03-12 |
NCT06307067 | Not yet recruiting | Improving Care for Uncomplicated URinary Tract Infection-associated Symptoms in Primary Healthcare Settings in INDOnesia | In the present study, we aim to analyze the impact of the introduction of a urinary dipstick test for patients presenting with uncomplicated UTI-associated symptoms on antibiotic prescription in primary health care in Indonesia. In addition, the knowledge of HCW regarding antibiotics and prudent use of antibiotics in t... | - EligibilityCriteria: Inclusion Criteria: All adult patients with uncomplicated urinary tract infection Exclusion Criteria: patients who have recurrent episodes of uncomplicated UTI, pregnant women, and patients with recent antibiotic use (any antibiotic use within 3 months before visit) - HealthyVolunteers: No - G... | 2024-03-12 |
NCT06307054 | Recruiting | CLL-1 CAR-NK Cells for Relapsed/Refractory AML | This study is a single-arm, open-label, dose-escalation clinical trial aimed at exploring the safety, tolerability, and pharmacokinetic characteristics of the CLL-1 CAR NK cells, as well as providing preliminary observations on its efficacy in subjects with relapsed/refractory acute myeloid leukemia. | - EligibilityCriteria: Inclusion Criteria: Age 18-70 years, gender unrestricted; Expected survival time exceeds 12 weeks; ECOG score 0-2; Meets the 2022 WHO criteria for acute myeloid leukemia and flow cytometry shows ≥70% expression of CLL1 in leukemia cells; or immunohistochemistry shows CLL1 expression ≥50% and me... | 2024-03-12 |
NCT06307028 | Recruiting | Sistas Informing Sistas on Topics About AIDS and Prevention (SISTA-P) | In this project, the investigators will provide a new HIV prevention training and empowerment sessions to Black women in Washington D.C. who are at high risk for getting HIV. This training is tailored to the experience of Black women and seeks to reduce the high HIV transmission rates in the Black community. | - EligibilityCriteria: Inclusion Criteria: Black women are eligible if you: Have sex with men Are age 18+ Live in Washington D.C. Are not HIV+ Exclusion Criteria: HIV+ - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: Black women are eligible for this study. - M... | 2024-03-12 |
NCT06307015 | Not yet recruiting | De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) | The goal of this prospective clinical trial is to determine if HPV-associated oropharyngeal squamous cell carcinoma that is non-hypoxic on FMISO PET can be successfully treated with a lower dose of radiation therapy.
The main questions it aims to answer are:
What is the pathologic complete response rate in patients s... | - EligibilityCriteria: Inclusion Criteria: Age > 18 years Histologically confirmed cT1-2N1-2b oropharyngeal squamous cell carcinoma or cTxN1-2 carcinoma of unknown primary p16 positive (70% nuclear and cytoplasmic staining) and HPV positive (genotyping via PCR) tumours of the tonsil, base of tongue, glossotonsillar su... | 2024-03-12 |
NCT06307002 | Not yet recruiting | Evaluating What's My Method? in Barbados | The purpose of this study is to measure the impact of the What's My Method game on participants' sense of agency, education, and empowerment around contraceptive decision-making. Patients receiving standard of care contraceptive counseling will be compared to those who play the game in addition to counseling. | - EligibilityCriteria: Inclusion Criteria: - English-speaking Capable of using a tablet Childbearing individuals Individuals/Couples seeking family planning counseling (one response collected per couple) Exclusion Criteria: Unable to provide informed consent due to intellectual or physical impairment - Under the age... | 2024-03-12 |
NCT06306989 | Recruiting | Observational Clinical Study of Letermovir for Preventing CMV Infection After Allo-HSCT | The goal of this observational study is to get a series of clinical data related to the prevention of CMV infection after allo-HSCT with letemovir. The main question it aims to answer are:
Efficacy and safety of letemovir for the prevention of CMV infection after allo-HSCT.
Optimal initiation of letemovir to prevent C... | - EligibilityCriteria: Inclusion Criteria: Biological age not less than 14 years. Positive CMV serology. No detectable CMV-DNA from plasma samples taken 5 days prior to randomization into groups. Exclusion Criteria: severe hepatic impairment; estimated creatinine clearance of less than 10 ml/min; current or recent r... | 2024-03-12 |
NCT06306963 | Not yet recruiting | Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in GAVE | The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding. It can also cause symptoms such as abdominal pain and nausea. By participating in this study, you will help us ... | - EligibilityCriteria: Inclusion Criteria: Patients >18 years of age with endoscopic evidence of Gastric Antral Vascular Ectasia. Willingness to participate in the study Capacity to provide informed consent. No evidence of organic, systemic, or metabolic disease (e.g. diabetes mellitus) to explain the symptoms on rout... | 2024-03-12 |
NCT06306924 | Not yet recruiting | UNC Metastatic Cancer Radiation Therapy Registry | The purpose of this registry is to collect clinical data from participants attending UNC Hospitals who present with metastatic cancer and are evaluated to receive radiation therapy as part of their standard of care treatment. The goal of this study is to provide a foundation for studies designed to identify projects ac... | - EligibilityCriteria: Inclusion Criteria: 1. Written informed consent was obtained to participate in the study and HIPAA authorization for release of personal health information. Ability to understand and willingness to sign informed consent 3. Has been diagnosed with or is suspected to have metastatic cancer. 4. Age... | 2024-03-12 |
NCT06306911 | Recruiting | Bioavailability of Aronia Melanocarpa | The main objective of this study is to study the bioavailability and kinetics of acute Aronia Melanocarpa supplementation in healthy young (18-35 years) and older adults (55-75 years) adults. During the test day, participants will ingest a drink consisting of Aronia Melanocarpa extract (AME). The bioavailability and ki... | - EligibilityCriteria: Inclusion Criteria: BMI between 18-35 kg/m2 Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg Stable body weight (weight gain or loss < 3 kg in the past three months) Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study ... | 2024-03-12 |
NCT06306898 | Not yet recruiting | Intra-Arrest-Ventilation in Human Cadavers | The study investigates the influence of non-synchronized, intermittent positive pressure ventilation (IPPV), as recommended in the current resuscitation guidelines of the European Resuscitation Concil (tidal Volume (Vt) = 5-6 mL/kg body weight, respiratory rate = 10 min-1) and Chest Compression Synchronized Ventilation... | - EligibilityCriteria: Inclusion Criteria: > 17 Years of Age Exclusion Criteria: Adult respiratory distress syndrome (ARDS) Severe lung or thoracic injuries pneumothorax Abnormal airways Tracheostoma severe aspirations - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge:... | 2024-03-12 |
NCT06306885 | Not yet recruiting | Effects of Early Sleep After Action Observation and Motor Imagery After Metacarpal Fracture Surgery | The study aimed to investigate the effects of early sleep after action observation and motor imagery (AOMI) training sessions on manual dexterity in patients with hand immobilization after surgical fixation for metacarpals and phalanges fractures.
Fifty-one patients with hand immobilization for surgical fixation of IV... | - EligibilityCriteria: Inclusion Criteria: Surgical fixation for IV or V MTC or P1 fracture at the level of the right hand Age 18-40 years old Right-hand dominance Exclusion Criteria: Damage to additional hand structure requiring surgery (e.g. tendons, ligaments and nerves) Occurrence of left upper limb injuries Pos... | 2024-03-12 |
NCT06306872 | Recruiting | A Clinical Trial to Evaluate the Relative Bioavailability of New and Old ABSK-011 Capsules | The main objective of which is to evaluate the relative bioavailability and PK characteristics of new and old ABSK-011 capsules in a single oral dose | - EligibilityCriteria: Inclusion Criteria: Healthy subjects aged between 18 and 45 years (including 18 and 45 years) at the time of screening; Male ≥50 kg, female ≥45kg, body mass index (BMI) between 19 and 28 (including 19 and 28), BMI= weight (kg)/height (m) 2; Physical examination, laboratory examination and other... | 2024-03-12 |
NCT06306859 | Not yet recruiting | Development of Health Monitoring System on Patient's Well Being in Dialysis Context | One of the goals in the Sustainable Development Goals (SDGs) is the availability of a healthy and prosperous life for all ages. This goal mentions health priorities i.e. non-communicable diseases. Chronic kidney failure (CRF) is one of the non-communicable diseases that is the main cause of death and disability both in... | - EligibilityCriteria: Inclusion Criteria: >18 years old has been undergoing hemodialysis >3 months has smartphone Exclusion Criteria: emergency hemodialysis - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult | 2024-03-12 |
NCT06306846 | Recruiting | Neoadjuvant SBRT in Localized Advanced HNSCC | The response rate of HNSCC to immune checkpoint blockade was not satisfied. Improving the mPR rate of neoadjuvant immunotherapy through the combination with other treatment methods is an important way to further improve the prognosis of such patients. This study aims to explore the efficacy and safety of PD-1 monoclona... | - EligibilityCriteria: Inclusion Criteria: Pathologically confirmed initially resectable Localized advanced head and neck squamous cell carcinoma，and plan for surgical resection. Immunohistochemical confirmed the HPV status through P16 immunostaining. Male or female, Between the aged from 18 to 70 years, Able to provi... | 2024-03-12 |
NCT06306833 | Recruiting | The Surface EMG Biofeedback as an Alternative Therapy to Reduce Chronic Low Back Pain | The prevalence of chronic low back pain (CLBP) among the Pakistani population is reported to be as high as 78% leading towards different physiological and psychosocial alterations with the worst cases suffering from disabilities. CLBP is a multifactorial phenomenon in which age, gender, comorbidities, lifestyle conditi... | - EligibilityCriteria: Inclusion Criteria: Individuals who constantly experience low back pain for the last three months. Individuals who seek care from healthcare provider due to low back pain Individuals with average pain intensity, were assessed using the Brief Pain Inventory (BPI) over the past week ≥ 2 on a 0-10 ... | 2024-03-12 |
NCT06306820 | Not yet recruiting | Ultrasound Guided Recruitment Manauvere Versus Individualized Positive End Expiratory Pressure in Pediatric Patients Undergoing Laparoscopic Abdominal Surgery | The aim of this prospective randomized controlled study is to compare the effect of US-guided Recruitment Manauvere (RM) versus individualized positive end-expiratory pressure (PEEP) on oxygenation and preventing respiratory complications in pediatric patients undergoing laparoscopic abdominal surgeries. | - EligibilityCriteria: Inclusion Criteria: Age from 3 to 8 years. Both sexes. American Society of Anesthesiologists (ASA) physical status I-II. Children scheduled for elective laparoscopic abdominal surgeries. Exclusion Criteria: Parental refusal. Bronchial asthma or any preexisting chest disease. Congenital deformi... | 2024-03-12 |
NCT06306794 | Not yet recruiting | Reducing Pain Levels and Increasing Comfort of Premature Infants During Aspiration | The aim of this study was to investigate the effect of using amigurumi octopus on the pain and comfort of the newborn in premature infants undergoing endotracheal aspiration.
It is a randomized controlled quasi-experimental design. The study will be conducted in the neonatal intensive care unit of Health Sciences Univ... | - EligibilityCriteria: Inclusion Criteria: Gestational age range of 26-36 weeks The baby should be between postnatal day 0 and 5 (Postnatal day of baby should be between 0 and 5 days.) Need for invasive mechanical ventilator support Need for endotracheal aspiration No analgesic, opioid and sedative medication was appl... | 2024-03-12 |
NCT06306781 | Not yet recruiting | A Clinical Trial Evaluating the Safety, Tolerability, and Preliminary Efficacy of HCL001 Cell Injection (Homologous Allogeneic Hepatocytes) in Patients With Decompensated Cirrhosis | This study protocol is designed to evaluate the clinical efficacy, safety, and tolerability of HCL001 cell injection in the treatment of decompensated cirrhosis. The aim is to provide stronger evidence for the clinical application of HCL001 cell injection in the treatment of decompensated cirrhosis, thereby attempting ... | - EligibilityCriteria: Inclusion Criteria: When signing the informed consent form, individuals between the ages of 18 to 75 years (inclusive, including the boundary values) are eligible, and there are no restrictions based on gender. According to the "Guidelines for the Diagnosis and Treatment of Cirrhosis (2019 Editi... | 2024-03-12 |
NCT06306768 | Not yet recruiting | Remote Therapeutic Monitoring Exercise Tracking | The purpose of this study is to examine physical activity and exercise behaviors in people with Parkinson's Disease and Multiple Sclerosis over the course of 1-year using a cloud-based remote monitoring platform. | - EligibilityCriteria: Inclusion Criteria: Are ambulatory as their primary means of mobility without an assistive device except for single point cane or walking sticks in community Have a diagnosis of Parkinson's disease (Hoehn and Yahr 1-3), Parkinsonism, or Multiple Sclerosis Personal goal and willingness to address... | 2024-03-12 |
NCT06306755 | Not yet recruiting | Effectiveness of Risk-based Sequential Screening for Esophageal and Gastric Cancer | To evaluate the feasibility, applicability, effectiveness, and health-economic value of the risk-based sequential screening modality for esophageal and gastric cancers, the investigators aim to initiate a community-based randomized controlled trial in Xun County, Henan Province, which is a high-risk region of upper gas... | - EligibilityCriteria: Inclusion Criteria: Permanent residency in the target villages in Xun County, Henan Province, China; Aged 50 to 69 at the enrollment; Voluntarily participate in this study and provide informed consent. Exclusion Criteria: Had a history of endoscopic examination within 5 years prior to the init... | 2024-03-12 |
NCT06306742 | Recruiting | Open-label Placebo in Manual Therapy | to investigate the effects of placebo in patients affected by low-back pain. | - EligibilityCriteria: Inclusion Criteria: Adult patients (+18 years) who complain of chronic non-specific low back pain for at least 3 months with or without pain exacerbations at the time of recruitment, will be included. -Patients will need to have a diagnosis of low back pain made by a physician Exclusion Criter... | 2024-03-12 |
NCT06306729 | Not yet recruiting | Computational Assessment of Bioprosthetic Aortic Valve Function | Bioprosthetic valves are usually made of biological tissue that are mounted to a frame and are designed to function similarly to a healthy natural valve. Edwards Magna Ease and Intuity Elite bioprosthetic valves have similar leaflets and mounting designs. However, the valves are implanted in the patient in different wa... | - EligibilityCriteria: Inclusion Criteria: Male and female patients aged 18 years or over. Patients diagnosed with aortic valve disease, and scheduled to undergo Edwards Magna Ease or Intuity Elite and free of exclusion criteria below. The patient is willing and able to understand the Patient Information Sheet and pro... | 2024-03-12 |
NCT06306716 | Not yet recruiting | Single Center Clinical Study on New Negative Pressure Wound Therapy Dressing in the Management of Chronic & Acute Wounds | The purpose of the study is to evaluate the clinical performance of a new Negative Pressure Wound Therapy dressing in the management of chronic and acute wounds. | - EligibilityCriteria: Inclusion Criteria: Subject has provided written informed consent. Subject is 18 years of age or over. Subject is able and willing to comply with study requirements. Subject is suitable to participate in the study in the opinion of the Investigator. Subject is an inpatient at time of enrollment ... | 2024-03-12 |
NCT06306703 | Not yet recruiting | Comparison of Teaching Methods of Pelvic Floor Muscle Contraction in Women | The aim of our study; To evaluate the effectiveness of different teaching methods on correct pelvic floor muscle contraction in women who have not received pelvic floor muscle training (PFMT) before. Women who come to the gynecology and obstetrics clinic for examination and volunteer for the study will be randomized wi... | - EligibilityCriteria: Inclusion Criteria: volunteering to participate in the study, getting a score of 25 or more from the "Mini mental Test", having pelvic floor muscle contraction ability, not having received pelvic floor muscle training before, vaginal examination and volunteering for education. Exclusion Criteri... | 2024-03-12 |
NCT06306690 | Recruiting | Biomarkers in Retinitis Pigmentosa | The objective of this study is to discover biomarkers that demonstrate a correlation between the severity of retinitis pigmentosa (RP) and the thickness of the retinal pigment epithelium (RPE). These biomarkers will serve as prognostic indicators for various kinds of retinitis pigmentosa. The objective of this study is... | - EligibilityCriteria: Inclusion Criteria: Patients who are able to read and sign informed consent Patients with Retinitis pigmentosa confirmed by genetic test. Patients older than or equal to 18 years of age Exclusion Criteria: Other retinal diseases such as macular hole, retinal detachment, macular neovascularizat... | 2024-03-12 |
NCT06306677 | Not yet recruiting | Accuracy of an AI-clinical Knowledge-based Hybrid System for Detecting Periodontitis in OPG Images | Periodontitis is highly prevalent and rarely detected and treated in the earlier stages of the disease. Orthopantomography (OPG) is the most frequently taken dental radiograph around the world, and its systematic screening may contribute to early detection of periodontitis and access to the needed level of care. The in... | - EligibilityCriteria: Inclusion Criteria: Aged 18 and above Having taken the OPG image Exclusion Criteria: Edentulous mouth - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients seeking care at Shanghai Ninth People's Hospit... | 2024-03-12 |
NCT06306651 | Not yet recruiting | High Flow Nasal Cannula and Conventional Oxygen Therapy in the Postoperative Management of Patients With Mild to Moderate Obstructive Sleep Apnea | This study aims to compare the effectiveness of conventional oxygen therapy oxygen and high-flow nasal cannula therapy on oxygen saturation (SpO2), measuring number of SpO2 drop >4% of base line oxygen saturation (o2 desaturation index), length of the ICU stay, and the need of use supplemental continuous positive airwa... | - EligibilityCriteria: Inclusion Criteria: Age group from 21 - 40 years old. Both sexes. Mild to moderate obstructive sleep apnea (OSA) patients with STOP-BANG score less than 5. OSA patients undergoing non cardiac surgeries. Patients who will undergo scheduled elective surgeries under general anesthesia. Exclusion C... | 2024-03-12 |
NCT06306638 | Not yet recruiting | Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction | This phase I/II trial studies the side effects of interstitial photodynamic therapy following palliative radiotherapy and how well it works in treating patients with inoperable malignant central airway obstruction. Patients who have advanced stage cancer tumors in the lung can often have the breathing passages to the l... | - EligibilityCriteria: Inclusion Criteria: Age >= 18 years of age Eligibility checklist before registration requires review of case by the interventional pulmonologist/s and radiation oncologist/s to approve anatomic feasibility of an airway intervention and palliative radiotherapy Patients with pathologic diagnosis o... | 2024-03-12 |
NCT06306625 | Not yet recruiting | REmote COnditioning in Out-of-Hospital Cardiac Arrest | Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion process... | - EligibilityCriteria: Inclusion Criteria: Age between 18 and 80 years old Out-of-hospital cardiac arrest, whatever the initial cardiac rhythm (shockable or non-shockable) or the duration of no-flow and low-flow, Presence of a witness who may or may not have started cardiopulmonary resuscitation, or patient seen alive... | 2024-03-12 |
NCT06306612 | Recruiting | CytoREductive prostAtectomy for Poly-metastatic Hormone sensiTIVE Prostate Cancer | The goal of this clinical trial is to compare systemic therapy combined with cytoreductive prostatectomy with standard of care (SOC) in de novo poly-metastatic hormone sensitive prostate cancer (de novo pmHSPC). The main questions it aims to answer are:
To explore the clinical benefit and safety of systemic therapy co... | - EligibilityCriteria: Inclusion Criteria: Fully understand the purpose of this trial and sign a written informed consent; Men aged 18-85 years; have histologically or cytologically confirmed adenocarcinoma of the prostate; Have multiple metastatic disease, defined as follows: according to RECIST v1.1, metastatic dise... | 2024-03-12 |
NCT06306586 | Not yet recruiting | A Digital Treatment for Adolescents With Eating Disorders | The goal of this feasibility study is to evaluate the feasibility and preliminary clinical outcomes of a personalized digital treatment for adolescents with eating disorders. The main objectives are to:
i) Evaluate whether a personalized digital treatment for adolescents with eating disorders are feasible in a child a... | - EligibilityCriteria: Inclusion Criteria: A. Diagnosed with F50.1 Atypical anorexia nervosa, F50.3 Atypical bulimia nervosa, F50.8 Other eating disorders, F50.9 Eating disorder, unspecified B. Age between 16 and 18 years. C. Stable dose of medication for a co-morbid psychiatric treatment for six weeks and who conti... | 2024-03-12 |
NCT06306560 | Not yet recruiting | A Study of Adebrelimab Combined With Famitinib and Chemotherapy in the Treatment of ES-SCLC. | This is a single arm, multi-center, phase II trial to evaluate the efficacy, and safety of adebrelimab combined with famitinib and chemotherapy for the treatment of first-line extensive stage small cell lung cancer. | - EligibilityCriteria: Inclusion Criteria: Age: 18-80 years old, male or female Patients with pathologically confirmed extensive stage small cell lung cancer (according to the Veterans Administration Lung Study Group, VALG staging) Never received prior systemic therapy for extensive stage small cell lung cancer Have a... | 2024-03-12 |
NCT06306547 | Not yet recruiting | Clinical Study Cohort of Idiopathic Inflammatory Myositis | Idiopathic inflammatory myositis (IIM), also known as myositis, are a heterogeneous group of diseases characterized by chronic inflammation of striated muscles and skin, with different clinical manifestations, treatment responses, and prognosis. This project will build a clinical follow-up cohort for idiopathic inflamm... | - EligibilityCriteria: Inclusion Criteria:Subjects must meet the following criteria for inclusion in this study: meet the 2017 EULAR/ACR classification criteria for inflammatory myopathy (IIM) or the 2018 ENMC-DM classification criteria (see above), plus: Age≥ 18 years old and ≤ 75 years old Meet the 2017 EULAR/ACR cl... | 2024-03-12 |
NCT06306534 | Recruiting | Auditory Intranerve Stimulation Study | This feasibility clinical investigation is designed to answer the question of whether auditory brainstem responses can be safely elicited by acute electrical stimulation within the human auditory nerve. | - EligibilityCriteria: Inclusion Criteria: Written informed consent Patients who will undergo an acoustic neuroma removal surgery and are functional deaf Age ≥ 18 years Women with childbearing potential: willingness to use a reliable contraceptive method (e.g. copper intrauterine devices or hormonal methods) after con... | 2024-03-12 |
NCT06306521 | Recruiting | An Adaptive Clinical Trial of BeginNGS Newborn Screening for Hundreds of Genetic Diseases by Genome Sequencing | The goal of this clinical trial is to test a new method for newborn screening using whole genome sequencing, called BeginNGS. Parents will be approached to provide informed consent to enroll their newborns in prenatal, postnatal, and outpatient settings. The main questions this study aims to answer are:
What is the ut... | - EligibilityCriteria: Inclusion Criteria: Neonates (<28 days old) at enrollment sites. Parents must have identified a primary care provider (or group). Exclusion Criteria: Neonates whose mother is less than 18 years of age. Neonates who are wards of the state. Neonates whose parent/legal guardian is unable to provi... | 2024-03-12 |
NCT06306508 | Recruiting | Effect of Parental Attitude on Functional and Physical Level of Children With Cystic Fibrosis | Some parents may be more protective of children with CF due to concerns about worsening of the disease due to infection, which can affect their functional level. The goal of this observational study is to learn about the family's protective approach to the functioning and disease course of children with cystic fibrosis... | - EligibilityCriteria: Inclusion Criteria: For a child To be between 7-17 years old, Living with family or caregiver. For the parent Being the mother, father or other caregiver of the child, Voluntarily agreeing to participate in the study on behalf of both the child and oneself. Exclusion Criteria: For the child... | 2024-03-12 |
NCT06306482 | Not yet recruiting | Determination of Posture in Patients With Restrictive and Obstructive Lung Disease | The aim of this study is to determine posture and posture related factors in patients with restrictive and obstructive lung disease. | - EligibilityCriteria: Inclusion Criteria: Chronic Obstructive Pulmonary Disease Group Inclusion Criteria: Over 55 years old, Stage 1-2-3-4 according to the GOLD, Being clinically stable for the last 4 weeks. Chronic Obstructive Pulmonary Disease Group Exclusion Criteria: Receiving long-term oxygen therapy, Having ... | 2024-03-12 |
NCT06306456 | Recruiting | A Phase Ib/II Clinical Study of GH21 Capsules Combined With Osimertinib Mesylate Tablets in Patients With NSCLC | This study, including phase Ib , phase IIa and phase IIb, aims to evaluate the safety, tolerability, PK profile, efficacy and to determine the RP2D of GH21 capsules combined with Osimertinib mesylate tablets in NSCLC patients with EGFR mutations. | - EligibilityCriteria: Inclusion Criteria: Subjects or their legal representatives can understand and voluntarily sign the written ICF (before the start of screening and any study procedures); Male or female subjects aged ≥18 years; Advanced NSCLC patients with EGFR mutations confirmed by cytological or histological ... | 2024-03-12 |
NCT06306443 | Not yet recruiting | Buprenorphine for Individuals in Jail | This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metropolitan jail. An open-label design will randomly assign 240 adults with moderate-to-severe OUDs who are soon-to-be-released from jail to either XR-B (n=120) or SL... | - EligibilityCriteria: Inclusion Criteria: Adult male or female inmates at participating jail who are eligible for release within 120 days (sentenced and/or pretrial [note: individuals who might be sentenced to state/federal prison will be excluded]); Those individuals who are pre-trial and/or sentenced who are comple... | 2024-03-12 |
NCT06306430 | Not yet recruiting | Detection of Lipoarabinomannan in Urine Evaluation of the STANDARDTMF TBLAMFIA and Its Impact on the Initial TB Diagnosis | Evaluation of the performance of an in vitro test, the STANDARDTM F TB LAM Ag FIA (SD BIOSENSOR, INC.) for the early diagnosis of tuberculosis (TB) infection. This test is for in vitro professional diagnostic use and intended as an aid to early diagnosis of tuberculosis infection. The test will be used according to the... | - EligibilityCriteria: Inclusion Criteria: Inclusion criteria for PTB, PNTM and extraPTB: Adult subjects with documented active pulmonary TB, pulmonary NTM or extrapulmonary TB Subjects who have signed informed consent Aged ≥18 years Inclusion criteria for HC: healthy donors who have signed informed consent aged ≥ ... | 2024-03-12 |
NCT06306417 | Recruiting | A Randomized Controlled Trial of Acupuncture for Insulin Resistance in Patients With Polycystic Ovary Syndrome | To determine the efficacy and safety of 2 different treatment modalities: 1) acupuncture plus lifestyle management (treatment group), 2) placebo plus lifestyle management (control group) in the treatment of insulin resistance in PCOS patients. | - EligibilityCriteria: Inclusion Criteria: For the PCOS group, PCOS diagnosis according to Rotterdam criteria 2003 with at least two of the following three symptoms: (1) infrequent ovulation or anovulation; (2) hyperandrogenism or clinical manifestations of high blood androgen; (3) ultrasound findings of polycystic ov... | 2024-03-12 |
NCT06306404 | Not yet recruiting | Improving Sleep and Mood in the Peri-menopause | The perimenopause is known as a vulnerable period for some women, with noticeable somatic and psychological issues. Aside from climacteric symptoms, insomnia and depression are common. About half of women during the peri-menopausal period experience sleep problems like problems falling asleep, awakening during the nigh... | - EligibilityCriteria: Inclusion Criteria: Age between 40-55 years old Insomnia severity index score =>10 Green Climacteric Score =>13 Self-considered capability of completing online questionnaires and diaries in Dutch Exclusion Criteria: CBTi treatment in past 3 months Bipolar disorder or psychotic disorder Contra-... | 2024-03-12 |
NCT06306391 | Recruiting | Pharmacokinetics of Intravenous and Intranasal Formulations of Naloxone in Healthy Volunteers. | This is a phase I interventional clinical trial and the aim will be to characterize the PK and PD of two formulations of naloxone (intranasal and intravenous) in healthy subjects, which will be used to verify/validate nasal-CNS-PBPK (Physiologically Based Pharmacokinetic) model predictions following intranasal dosing. | - EligibilityCriteria: Inclusion Criteria: Healthy male or female volunteers according to physical examination, vital signs (blood pressure, heart rate and body temperature), ECG and safety laboratory parameters and results should be within normal ranges or considered as non-clinically relevant by the investigator. Ag... | 2024-03-12 |
NCT06306378 | Recruiting | The Relationship Between Social Memory Disorders and Sleep Spindles in Children With Autism Spectrum Disorder | Research background and project basis
Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterized by social disorders and repetitive stereotypical behavior. Social memory impairment is a significant feature of ASD patients, and the specific pathogenesis of social memory impairment in ASD pat... | - EligibilityCriteria: Inclusion Criteria: Children with ASD diagnosed through DSM-V (Healthy controls do not have this requirement) IQ score ≥ 75（WISC-IV，Wechsler Intelligence Scale for Children） Age: 6-18 Not receiving psychotropic medication (Or stopping medication for at least 2 weeks before the experiment) Exclu... | 2024-03-12 |
NCT06306365 | Recruiting | Effects of Modern Board Games on Well Being in Older Adults | The aim of the study is to assess the effects of an intervention using modern board game-based learning in a sample of older individuals. The evaluation will focus on determining if there is a change in executive functions, social participation, and participants' perception of well-being. | - EligibilityCriteria: Inclusion criteria: Be residents of the Centro Doctor Villacián (Valladolid). Willing to commit to the study. Have literacy skills. Exclusion criteria: · Presentation of advanced dementia case. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 65 Years - MaximumAge: 1... | 2024-03-12 |
NCT06306339 | Not yet recruiting | A Study to Assess the Efficacy and Safety of Burfiralimab (hzVSF-v13) and DMRD (Disease-modifying Antirheumatic Drug) | The goal of this clinical trial is to evaluate the efficacy and safety of intravenous infusions of burfiralimab (hzVSF-v13) when added to Disease-Modifying Antirheumatic Drug (DMARD) treatment as Standard of Care (SOC) in participants with moderate to severe Rheumatoid Arthritis (RA). | - EligibilityCriteria: Inclusion Criteria: Participant has a diagnosis of adult-onset RA for at least 3 months prior to Screening, as defined by the 2010 ACR/European League Against Rheumatism (EULAR) classification criteria. Participant has moderate to severe RA at Screening and Baseline. Participant has had an inade... | 2024-03-12 |
NCT06306326 | Not yet recruiting | 3D Facial Scanning for Evaluating Autologous Fat Grafting in Craniofacial Deformities | Treatment of craniofacial deformities is a significant topic in oral and maxillofacial surgery, and autologous fat grafting has become one of the main methods for treating facial concave deformities. However, the instability of its treatment effect has always been a bottleneck in this field, mainly due to the uncertain... | - EligibilityCriteria: Inclusion Criteria: Facial soft tissue volume deficiency deformity caused by congenital/acquired factors, meeting the indications for autologous fat grafting surgery. Good physical health, without severe systemic diseases or infectious diseases. Not pregnant and without plans for pregnancy. Sign... | 2024-03-12 |
NCT06306313 | Not yet recruiting | Effects of Robot-Assisted Rehabilitation on Upper Extremity Functions in Chronic Stroke | The most common problem caused by stroke is motor activity limitation that reduces muscle movement and mobility. But stroke can also lead to sensory and cognitive impairment. Additionally, the ability to independently carry out activities of daily living and participate in social and community life is greatly reduced. ... | - EligibilityCriteria: Inclusion Criteria: Having had a single stroke Having had at least 6 months since the stroke Having hemiparesis/hemiplegia following the stroke Having mental health sufficient to meet all evaluation and treatment procedures in the study Exclusion Criteria: Having a history of disease other tha... | 2024-03-12 |
NCT06306300 | Recruiting | Randomized Open-label and Non-inferiority Clinical Trial | Up to 650,000 people in Brazil are living with chronic hepatitis c virus (HCV) infection. Hepatitis C is a silent disease, and up to 20% of cases can progress to liver cirrhosis and its complications. Rapid tests for diagnosis of HCV infection and non-invasive methods for detecting liver cirrhosis are available in the ... | - EligibilityCriteria: Study I and Sub-Study Inclusion Criteria: - Age between 18-79 years-old Exclusion Criteria: Presence of a disease that need urgent/emergency treatment and/or acute febrile illness, such as COVID-19, Dengue, Zyca virus infection or Chikungunya Lack of capacity to sign the informed consent or r... | 2024-03-12 |
NCT06306287 | Recruiting | Adolescent Screening and Personalized Intervention Resource for Enhancement of Behavioral Health and Substance Use | Only a small fraction of youth who are beginning to experience behavioral health problems and use alcohol or illicit drugs receive needed treatment services due to the lack of accessible, effective early intervention resources. The goal of this clinical trial is to compare a personalized brief web-based early intervent... | - EligibilityCriteria: Inclusion Criteria: 12-17-years old live at home with at least one parent or parent figure reporting mild/moderate substance use reporting mental health issues sufficient English language skills for assessments and intervention Exclusion Criteria: a sibling has already participated in the stud... | 2024-03-12 |
NCT06306274 | Not yet recruiting | Topical Tacrolimus for Breast Cancer-related Lymphedema | The goal of this clinical trial is to investigate the effect of tacrolimus ointment in women with stage I or II breast cancer-related lymphedema. The main question it aims to answer are:
How tacrolimus affects breast cancer related lymphedema regarding subjective and objective measures (e.g. arm volume, lymphedema ind... | - EligibilityCriteria: Inclusion Criteria: Age over 18 years BCRL ISL stage I or II Pitting edema Postmenopausal or use of Contraceptive drugs Healthy opposite arm L-Dex score over 10 Exclusion Criteria: Pregnant, breast-feeding, or aiming to conceive within the next year Bilateral breast cancer Contralateral lympha... | 2024-03-12 |
NCT06306261 | Not yet recruiting | Controlling the Mental Health for a Better Response to Treatment in Patients With Ulcerative Colitis | The project aims to implement the Internet Of Thing (IoT) platform of the San Raffaele Hospital (OSR) with data from stress conditions perceived by the patient through the synergistic collaboration between patients, gastroenterologists and psychologists. | - EligibilityCriteria: Inclusion Criteria: - Patients in whom the ulcerative colitis has been diagnosed and eligible for advanced therapies Patients will be asked to sign an informed consensus before filling out the questionnaire. Exclusion Criteria: - Patients in whom the ulcerative colitis has not been diagnosed. ... | 2024-03-12 |
NCT06306248 | Recruiting | Immune Activation, Neural Plasticity and Depression | Major depressive disorder (MDD) is a chronic, recurring and potentially life-threatening illness that affects up to 10% of the population across the globe.Increasing evidence indicates a clear link between immune dysfunction and MDD.Moreover, an activation of inflammatory pathways is associated to a lack of clinical re... | - EligibilityCriteria: Inclusion Criteria: A depressive episode according to Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria in the course of MDD with: HDRS score > 17 Age 18-65 years; In treatment with TSD+LT Signed informed consent, able to understand, speak and write the national language E... | 2024-03-12 |
NCT06306222 | Recruiting | Thulium Fiber Laser vs. Holmium:YAG Laser for the Ureteroscopic Treatment of Patients With Urinary Stone Disease | This is a randomized controlled trial which aims to compare the efficacy and safety of Thulium fiber laser (TFL) and holmium:yttrium-aluminum-garnet (Ho:YAG) laser ablation during the treatment of upper urinary tract stone disease with flexible ureteroscopy, demonstrating clinical superiority of TFL. | - EligibilityCriteria: Inclusion Criteria: Renal/ureteral stones > 4 mm Exclusion Criteria: Anatomical abnormalities - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 99 Years - StdAgeList: Adult, Older Adult | 2024-03-12 |
NCT06306209 | Recruiting | Inflammatory Control of Antidepressant Efficacy: a Pharmaco-epigenetic Approach | Major depressive disorder (MDD) is a chronic, recurring and potentially life-threatening illness that affects up to 10% of the population across the globe.It posits that the increase in serotonin levels induced by Selective Serotonin Reuptake Inhibitors (SSRIs) does not affect mood per se, but enhances brain plasticity... | - EligibilityCriteria: Inclusion Criteria: A depressive episode according to Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria in the course of MDD with: HDRS score > 17 Age 18-65 years; In treatment with SSRIs Signed informed consent, able to understand, speak and write the national language Ex... | 2024-03-12 |
NCT06306196 | Not yet recruiting | Immunogenicity and Safety of Hecolin® in HIV Positive/Negative Adults and in Children | The primary goal of this clinical trial is to demonstrate non-inferiority of 30 µg of Hecolin® in healthy children, compared to healthy adults as measured by seroresponse rates (SR) of anti-HEV IgG titers, 4 weeks after 3 doses (0, 1 and 6 months) and to assess and descriptively compare safety profile data intra and in... | - EligibilityCriteria: Inclusion Criteria (healthy participants only): Healthy participants 2 to 45 years of age at enrollment, Participants/Parent(s)/LAR who have voluntarily given informed consent/assent, Participants/Parent(s)/LAR willing to follow the study procedures and available for the entire duration of the s... | 2024-03-12 |
NCT06306183 | Not yet recruiting | Effect of Vitamin C on Pain Reduction After an Emergency Department Visit | Emergency department (ED) clinicians often prescribe anti-inflammatory drugs (NSAIDs) to manage acute musculoskeletal (MSK) pain (e.g.: fracture, sprain, back pain). However, even short-term NSAIDs use can have significant gastrointestinal, cardiovascular, MSK and renal adverse effects. For this reason, some patients c... | - EligibilityCriteria: Inclusion Criteria: Age ≥ 18 years old Treated in the ED for acute MSK pain present ≤ 48 hours at triage (time to presentation for most acute MSK pain in our previous study) Numerical rating scale (NRS) pain intensity at triage of ≥ 4 on a 0-10 scale Discharged with instructions to take an NSAID... | 2024-03-12 |
NCT06306170 | Recruiting | Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART) | This is an observational mono-institutional study. Patients with gynecologic tumors treated with advanced radiotherapy- Image Guided Radiotherapy (IGRT), Intensity Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy (SBRT)- will be included and toxicity and outcomes analyzed. | - EligibilityCriteria: Inclusion Criteria: gynecologic cancer patients >18 years old treated with advanced radiotherapy techniques (IGRT, IMRT, SBRT) Exclusion Criteria: other tumors > 90 years old - Gender: Female - GenderBased: Yes - GenderDescription: Gynecologic tumor patients - MinimumAge: 18 Years - MaximumAge... | 2024-03-12 |
NCT06306157 | Not yet recruiting | Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome | Complex Regional Pain Syndrome (CRPS) is a rare and often debilitating chronic pain condition whereby individuals may experience extreme sensitivity, discoloration, and swelling of the affected area -- along with numerous other painful symptoms. There are currently a limited number of treatment options available to tho... | - EligibilityCriteria: Inclusion Criteria: Between 18 and 65 years old Meeting CRPS diagnostic criteria using the Budapest Clinical Diagnostic Criteria CRPS patients with severe pain (NRS>3) that affects their daily life. CRPS patients with pain and other symptoms for more than 3 months. Exclusion Criteria: Patients... | 2024-03-12 |
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